Leclerc C, Bourgeois E, Chedid L
Immunol Commun. 1979;8(1):55-64. doi: 10.3109/08820137909044706.
N-acetyl-muramyl-L-alanyl-D-isoglutamine (referred to as MDP for muramyl dipeptide) has been shown to enhance in vivo and in vitro immune responses to various antigens. It has previously been reported that in the case of T-dependent antigens, the adjuvant activity of MDP was mediated by a helper T-cell. Our present findings demonstrate that in vitro responses of nude mice spleen cells to T-independent, TNP-PAA or T-dependent SRBC can also be markedly increased by this synthetic adjuvant. Moreover, under the same conditions, MDP produced polyclonal activation.
N-乙酰胞壁酰-L-丙氨酰-D-异谷氨酰胺（称为胞壁酰二肽的MDP）已被证明可增强体内和体外对各种抗原的免疫反应。此前有报道称，在T细胞依赖性抗原的情况下，MDP的佐剂活性由辅助性T细胞介导。我们目前的研究结果表明，这种合成佐剂也可显著增强裸鼠脾细胞对T细胞非依赖性抗原、TNP-PAA或T细胞依赖性抗原SRBC的体外反应。此外，在相同条件下，MDP可产生多克隆激活。
