Kuratli Jasmin, Borel Nicole
Institute of Veterinary Pathology, University of Zurich, Zurich, Switzerland.
Front Microbiol. 2019 May 10;10:1053. doi: 10.3389/fmicb.2019.01053. eCollection 2019.
Water-filtered infrared-A-radiation (wIRA) is a promising therapeutic method, which is particularly used as supportive treatment for wound closure, and wound infection treatment and prevention. High penetration properties of the heat field and beneficial effects on wound healing processes predispose wIRA irradiation to be a non-invasive treatment method for bacterial infections in superficial tissues. Since still represents the leading cause of infectious blindness in third world countries (WHO http://www.who.int/topics/trachoma/en/) and wIRA displays beneficial effects on chlamydial infections without inducing cellular damage in eye models and also shows beneficial effects on wound healing, this irradiation technique might represent a promising future treatment for trachoma patients. To this end, further studies investigating shorter irradiation times or irradiation of in chronic infections [the chlamydial stress response (Bavoil, 2014)] as well as safety studies in animal models should clearly be performed.
水过滤红外A辐射（wIRA）是一种很有前景的治疗方法，尤其用作伤口闭合、伤口感染治疗与预防的辅助治疗。热场的高穿透特性以及对伤口愈合过程的有益作用，使wIRA照射成为一种用于治疗浅表组织细菌感染的非侵入性治疗方法。由于沙眼仍是第三世界国家感染性失明的主要原因（世界卫生组织http://www.who.int/topics/trachoma/en/），并且wIRA在眼部模型中对衣原体感染显示出有益作用且不引起细胞损伤，同时对伤口愈合也显示出有益作用，因此这种照射技术可能是沙眼患者未来一种很有前景的治疗方法。为此，显然应该开展进一步的研究，调查更短的照射时间或对慢性感染（衣原体应激反应（巴沃伊尔，2014年））的照射情况，以及在动物模型中的安全性研究。
