Drucker M M, Agatsuma Y, Drucker I, Neter E, Bernstein J, Ogra P L
Infect Immun. 1979 Feb;23(2):347-52. doi: 10.1128/iai.23.2.347-352.1979.
Lymphoproliferative responses of tonsillar tissue lymphocytes and peripheral blood lymphocytes to phytohemagglutinin and specific bacterial product antigens were studied in children undergoing tonsillectomy and adenoidectomy. Tonsillar tissue lymphocytes responded to optimal concentrations of phytohemagglutinin. Varidase, and streptolysin-O in a manner similar to peripheral blood lymphocytes. Higher base-line mitogenic activity in tonsillar lymphocytes was frequently associated with the presence of Staphylococcus aureus in the tonsils. Tonsillar tissue lymphocytes from 23% of the subjects with the highest base-line mitogenic activity manifested a decreased response to in vitro stimulation with mitogens or antigens. In subjects with such preactivated tonsillar lymphocytes, the proliferative responsiveness of blood lymphocytes to mitogen and antigens was markedly increased after tonsillectomy and adenoidectomy. These observations suggest the existence of in vitro correlates of cellular immunity to bacterial products in the mucosal surfaces. In addition, it is proposed that tonsils may possess immunosuppressive activity for peripheral blood lymphocytes, which may be related to local tonsillar infections.
对接受扁桃体切除术和腺样体切除术的儿童，研究了扁桃体组织淋巴细胞和外周血淋巴细胞对植物血凝素和特定细菌产物抗原的淋巴细胞增殖反应。扁桃体组织淋巴细胞对植物血凝素、链激酶和链球菌溶血素 - O的最佳浓度的反应方式与外周血淋巴细胞相似。扁桃体淋巴细胞较高的基线促有丝分裂活性常与扁桃体中金黄色葡萄球菌的存在有关。23%基线促有丝分裂活性最高的受试者的扁桃体组织淋巴细胞对有丝分裂原或抗原的体外刺激反应降低。在具有这种预激活扁桃体淋巴细胞的受试者中，扁桃体切除术和腺样体切除术后，血液淋巴细胞对有丝分裂原和抗原的增殖反应明显增加。这些观察结果提示在粘膜表面存在对细菌产物细胞免疫的体外相关指标。此外，有人提出扁桃体可能对外周血淋巴细胞具有免疫抑制活性，这可能与局部扁桃体感染有关。
