用佛波酯十四烷酸酯刺激特应性个体和非特应性个体的淋巴细胞。
Lymphocyte stimulation with phorbol myristate acetate in atopic and non-atopic individuals.
作者信息
Strannegård I L
出版信息
Int Arch Allergy Appl Immunol. 1979;58(2):175-81. doi: 10.1159/000232190.
Phorbol myristate acetate (PMA) was found to be a potent stimulator of DNA synthesis in human whole blood cell cultures. Stimulation with pokeweed mitogen was strongly enhanced by addition of PMA-activated cells. PMA responsiveness varied with age, being low or absent in newborns and very pronounced in adults. In atopic children, PMA responsiveness was normal or increased. The ratio of phytohemagglutinin to PMA responsiveness was significantly reduced in cultures from such children. This finding would be compatible with the hypothesis of a relative suppressor cell deficiency in atopic disease. The results of tests designed to detect suppressor and helper cell activity, added further support to this hypothesis.
佛波醇肉豆蔻酸酯乙酸盐（PMA）被发现是人类全血细胞培养中DNA合成的有效刺激物。加入经PMA激活的细胞后，商陆丝裂原的刺激作用得到显著增强。PMA反应性随年龄而异，新生儿的反应性较低或无反应，而成年人的反应性则非常明显。在特应性儿童中，PMA反应性正常或增强。这些儿童培养物中植物血凝素与PMA反应性的比率显著降低。这一发现与特应性疾病中相对抑制细胞缺陷的假说相符。旨在检测抑制细胞和辅助细胞活性的试验结果，进一步支持了这一假说。
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