Medical Imaging Center, the First Affiliated Hospital of Jinan University, Guangzhou, China.
Department of Imaging and Interventional Radiology, Research Centre for Medical Image Computing, The Chinese University of Hong Kong, China.
Exp Clin Endocrinol Diabetes. 2020 Nov;128(11):737-744. doi: 10.1055/a-0883-4955. Epub 2019 May 28.
This study aimed to investigate regional homogeneity in the first-: degree relatives of type 2 diabetes patients.
Seventy-eight subjects, including 26 type 2 diabetes patients, 26 first-: degree relatives, and 26 healthy controls, were assessed. All participants underwent resting-state functional magnetic resonance imaging scanning. The estimated regional homogeneity value was used to evaluate differences in brain activities.
In first-: degree relatives, we observed significantly decreased regional homogeneity in the left anterior cingulate cortex, left insula, and bilateral temporal lobes, and increased regional homogeneity in the left superior frontal gyrus, right anterior cingulate cortex, and bilateral posterior cingulate cortex compared to healthy controls. In type 2 diabetes patients, we detected altered regional homogeneity in the left anterior cingulate cortex, left insula, bilateral posterior cingulate cortex, and several other brain regions compared to healthy controls. Both first-: degree relatives and type 2 diabetes patients showed decreased regional homogeneity in the left superior temporal gyrus, right middle temporal gyrus, left anterior cingulate cortex, left insula, and increased regional homogeneity in the left superior frontal gyrus and bilateral posterior cingulate cortex.
These findings suggest that altered regional homogeneity in the left anterior cingulate cortex, left insula, left superior frontal gyrus, bilateral posterior cingulate cortex, and bilateral temporal lobes might be a neuroimaging biomarker of type 2 diabetes -: related brain dysfunction.
本研究旨在探讨 2 型糖尿病患者一级亲属的脑区局部一致性。
共纳入 78 名受试者，包括 26 名 2 型糖尿病患者、26 名一级亲属和 26 名健康对照者。所有参与者均接受静息态功能磁共振成像扫描。采用局部一致性估计值评估脑活动的差异。
与健康对照组相比，一级亲属组左侧前扣带回、左侧岛叶和双侧颞叶的局部一致性显著降低，左侧额上回、右侧前扣带回和双侧后扣带回的局部一致性显著增加。与健康对照组相比，2 型糖尿病患者左侧前扣带回、左侧岛叶、双侧后扣带回和其他一些脑区的局部一致性发生改变。与健康对照组相比，一级亲属和 2 型糖尿病患者左侧颞上回、右侧颞中回、左侧前扣带回、左侧岛叶的局部一致性降低，左侧额上回和双侧后扣带回的局部一致性增加。
这些发现表明，左侧前扣带回、左侧岛叶、左侧额上回、双侧后扣带回和双侧颞叶的局部一致性改变可能是 2 型糖尿病相关脑功能障碍的神经影像学生物标志物。
