Barnard R O, Geddes J F
Cancer. 1987 Oct 1;60(7):1519-31. doi: 10.1002/1097-0142(19871001)60:7<1519::aid-cncr2820600719>3.0.co;2-1.
A series of 241 gliomas (astrocytomas, oligodendrogliomas, glioblastomas, and subependymal giant-cell astrocytomas) was studied. This represents all the gliomas examined post mortem over 25 years at one hospital. Two hundred and one cases (85%) were apparently solitary tumors; of the 40 cases with multiple tumor foci, 23 (9.5%) were true multicentric gliomas. After excluding cases in which there was concomitant disease (neurofibromatosis, tuberose sclerosis, or multiple sclerosis), 18 cases of multicentric tumor (7.5%) remained. Multicentric tumors with different histologic appearances accounted for 2.9% of the series. Celloidin-embedded whole brain sections proved invaluable for the detection of microscopic neoplastic foci and unsuspected diffuse spread. The estimated incidence of multiplicity in gliomas is higher than in most series, but the findings suggest that detection of multifocal neoplastic change in these tumors is directly related to the extent to which the brain is sampled, and that figures obtained in this study may well underestimate the true incidence.
对241例胶质瘤（星形细胞瘤、少突胶质细胞瘤、胶质母细胞瘤和室管膜下巨细胞星形细胞瘤）进行了研究。这代表了一家医院25年来所有尸检的胶质瘤病例。201例（85%）明显为孤立性肿瘤；在40例有多个肿瘤病灶的病例中，23例（9.5%）为真正的多中心胶质瘤。排除伴有其他疾病（神经纤维瘤病、结节性硬化症或多发性硬化症）的病例后，仍有18例多中心肿瘤（7.5%）。具有不同组织学表现的多中心肿瘤占该系列的2.9%。火棉胶包埋的全脑切片对于检测微小肿瘤病灶和未被怀疑的弥漫性扩散非常有价值。胶质瘤中多灶性的估计发生率高于大多数系列报道，但研究结果表明，这些肿瘤中多灶性肿瘤变化的检测与脑取样的范围直接相关，本研究获得的数据很可能低估了真实发生率。
