流感病毒进入时血凝素和神经氨酸酶的竞争合作。
Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry.
机构信息
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Shandong Provincial Collaborative Innovation Center for Antiviral Traditional Chinese Medicine, Jinan 250355, China.
出版信息
Viruses. 2019 May 20;11(5):458. doi: 10.3390/v11050458.
The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry.
流感病毒的血凝素（HA）和神经氨酸酶（NA）在与唾液酸（SA）相互作用时具有拮抗活性，SA 是病毒附着的受体。HA 通过其受体结合位点与 SA 结合，而 NA 是通过去除 SAs 的受体破坏酶。HA 在病毒进入过程中的功能已被广泛研究，然而，对 NA 的检查长期以来一直集中在其在从感染细胞中释放子代病毒方面的作用上，并且 NA 在进入过程中的作用仍然未被充分认识。本文综述了目前对 HA 和 NA 在病毒进入过程中相互作用的作用的理解。
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