在一组土耳其女性中，尿中性粒细胞明胶酶相关脂质运载蛋白与先兆子痫有关。
Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women.
作者信息
Yuksel Semra, Ozyurek Sefik Eser, Acar Deniz Kanber, Ozdemir Cagdas, Guler Sebile, Kiyak Huseyin, Gedikbasi Ali
机构信息
a Department of Obstetrics and Gynecology , GOP Taksim Training and Research Hospital , Istanbul , Turkey.
b Department of Obstetrics and Gynecology , Bagcilar Training and Research Hospital , Istanbul , Turkey.
出版信息
Hypertens Pregnancy. 2019 Aug;38(3):157-162. doi: 10.1080/10641955.2019.1621887. Epub 2019 May 29.
We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P< 0.001). Using a cutoff value 252 ng/ml for urinary NGAL to confirm diagnosis of preeclampsia, sensitivity, and specificity were 92% and 91%, respectively. Urinary NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls.
我们研究了子痫前期患者尿中性粒细胞明胶酶相关脂质运载蛋白（NGAL）的最佳截断水平以确诊疾病。通过特异性酶联免疫吸附测定（ELISA）测量尿NGAL浓度。子痫前期患者的尿NGAL浓度显著高于对照组（均值分别为387 ng/ml和188 ng/ml；P<0.001）。使用尿NGAL截断值252 ng/ml来确诊子痫前期，敏感性和特异性分别为92%和91%。与血压正常的对照组相比，子痫前期女性的尿NGAL浓度显著升高。
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