Marco-Fuertes Ana, Marin Clara, Villora-Gonzalez José, Gimeno-Cardona Concepción, Artal-Muñoz Violeta, Vega Santiago, Montoro-Dasi Laura
Facultad de Veterinaria, Instituto de Ciencias Biomédicas, Universidad Cardenal Herrera-CEU, CEU Universities, Valencia, Spain.
Selvätica Veterinary Clinic, Valencia, Spain.
Front Vet Sci. 2024 Aug 9;11:1378346. doi: 10.3389/fvets.2024.1378346. eCollection 2024.
The increasing prevalence of antimicrobial resistance (AMR) and multidrug resistance (MDR) in microorganisms poses a significant concern in both human and veterinary medicine. Non-traditional companion animals (NTCAs), particularly popular amongst households with children, play a crucial role in AMR epidemiology due to their rising population. Indeed, it is known that some of these animals may act as reservoirs of zoonotic pathogens and thus be able to spread and transmit them to family members, along with their AMR, through their shared environment. It is therefore imperative to address this concern with the involvement of human, animal and environmental health professionals. This pilot study aimed to assess the prevalence and AMR patterns of spp. strains obtained from commensal mucosal and skin infection samples in NTC small mammals, with a focus on strains like methicillin-resistant spp. (MRS) that are critical in public health.
For this purpose, 81 animals of different small mammal species were sampled, assessing antimicrobial susceptibility to 27 relevant antimicrobial agents (AMAs) in human health using minimum inhibitory concentration assays, and interpreting them according to EUCAST and CLSI guidelines. The isolated i strains were identified by MALDI-TOF, with the predominant species being and .
Including all strains isolated, AMR was observed against all 27 AMAs, including six last-resort AMAs in human medicine. Additionally, over 85% of the strains exhibited MDR. These findings underscore the need to monitor AMR and MDR trends in companion animals and emphasise the potential role of NTCAs in spreading resistance to humans, other animals, and their shared environment, calling for a comprehensive "One Health" approach.
微生物中抗菌药物耐药性（AMR）和多重耐药性（MDR）的日益普遍在人类医学和兽医学中都引起了重大关注。非传统伴侣动物（NTCAs）在有孩子的家庭中特别受欢迎，由于其数量不断增加，在AMR流行病学中起着关键作用。事实上，已知其中一些动物可能是人畜共患病原体的宿主，因此能够通过共享环境将病原体及其AMR传播给家庭成员。因此，必须让人类、动物和环境卫生专业人员参与来解决这一问题。这项初步研究旨在评估从NTC小型哺乳动物的共生黏膜和皮肤感染样本中获得的 spp. 菌株的流行情况和AMR模式，重点关注对公共卫生至关重要的耐甲氧西林 spp.（MRS）等菌株。
为此，对81只不同小型哺乳动物物种的动物进行了采样，使用最低抑菌浓度测定法评估其对27种人类健康相关抗菌药物（AMAs）的抗菌敏感性，并根据欧盟CAST和CLSI指南进行解读。通过基质辅助激光解吸电离飞行时间质谱（MALDI-TOF）鉴定分离出的 i菌株，主要物种为 和 。
包括所有分离出的菌株，观察到对所有27种AMAs均有AMR，包括人类医学中的六种最后手段AMAs。此外，超过85%的菌株表现出MDR。这些发现强调了监测伴侣动物中AMR和MDR趋势的必要性，并强调了NTCAs在将耐药性传播给人类、其他动物及其共享环境方面的潜在作用，呼吁采取全面的“同一健康”方法。
