双生病毒及其相关DNA卫星编码的RNA沉默抑制子。
Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites.
作者信息
Rishishwar Rashmi, Dasgupta Indranil
机构信息
Department of Plant Molecular Biology, University of Delhi South Campus, New Delhi, 110021 India.
出版信息
Virusdisease. 2019 Mar;30(1):58-65. doi: 10.1007/s13337-018-0418-8. Epub 2018 Jan 16.
Abstract
In plants, RNA silencing provides a major line of defence against viruses. This antiviral immunity involves production of virus-derived small interfering RNAs (vsiRNAs) and results in specific silencing of viruses by vsiRNAs-guided effector complexes. As a counterattack against RNA silencing, many plant viruses encode suppressors of RNA silencing called viral suppressors of RNA silencing (VSRs), which interfere with the silencing pathway by various mechanisms. This review describes various methods that are being used to characterize viral proteins for suppressor function, VSRs found in geminiviruses and associated DNA satellites and their mechanisms of action.
摘要
在植物中，RNA沉默是抵御病毒的主要防线。这种抗病毒免疫涉及病毒衍生的小干扰RNA（vsiRNA）的产生，并通过vsiRNA引导的效应复合物导致病毒的特异性沉默。作为对RNA沉默的反击，许多植物病毒编码RNA沉默抑制子，称为病毒RNA沉默抑制子（VSR），它们通过各种机制干扰沉默途径。本综述描述了用于鉴定具有抑制功能的病毒蛋白的各种方法、双生病毒及其相关DNA卫星中发现的VSR及其作用机制。
相似文献
1
Suppressors of RNA silencing encoded by geminiviruses and associated DNA satellites.
Virusdisease. 2019 Mar;30(1):58-65. doi: 10.1007/s13337-018-0418-8. Epub 2018 Jan 16.
2
A Viral Suppressor Modulates the Plant Immune Response Early in Infection by Regulating MicroRNA Activity.
mBio. 2018 Apr 24;9(2):e00419-18. doi: 10.1128/mBio.00419-18.
3
Recent progress on gene silencing/suppression by virus-derived small interfering RNAs in rice viruses especially Rice grassy stunt virus.
Microb Pathog. 2018 Dec;125:210-218. doi: 10.1016/j.micpath.2018.09.021. Epub 2018 Sep 19.
4
Viral induction and suppression of RNA silencing in plants.
Biochim Biophys Acta. 2011 Nov-Dec;1809(11-12):601-12. doi: 10.1016/j.bbagrm.2011.04.005. Epub 2011 Apr 30.
5
Viral suppression of RNA silencing.
Sci China Life Sci. 2012 Feb;55(2):109-18. doi: 10.1007/s11427-012-4279-x. Epub 2012 Mar 15.
6
Virus counterdefense: diverse strategies for evading the RNA-silencing immunity.
Annu Rev Microbiol. 2006;60:503-31. doi: 10.1146/annurev.micro.60.080805.142205.
7
Biological chemistry of virus-encoded suppressors of RNA silencing: an overview.
Methods Mol Biol. 2012;894:39-56. doi: 10.1007/978-1-61779-882-5_3.
8
Satellite RNAs interfere with the function of viral RNA silencing suppressors.
Front Plant Sci. 2015 Apr 24;6:281. doi: 10.3389/fpls.2015.00281. eCollection 2015.
9
RNA-Targeted Antiviral Immunity: More Than Just RNA Silencing.
Trends Microbiol. 2019 Sep;27(9):792-805. doi: 10.1016/j.tim.2019.05.007. Epub 2019 Jun 15.
10
Impact of viral silencing suppressors on plant viral synergism: a global agro-economic concern.
Appl Microbiol Biotechnol. 2021 Aug;105(16-17):6301-6313. doi: 10.1007/s00253-021-11483-9. Epub 2021 Aug 23.
引用本文的文献
1
Variable infection mechanisms of mungbean yellow mosaic India virus in diverse species: New insights from differential gene expression.
Physiol Mol Biol Plants. 2025 Jan;31(1):153-162. doi: 10.1007/s12298-025-01547-9. Epub 2025 Jan 15.
2
REPercussions: how geminiviruses recruit host factors for replication.
Front Microbiol. 2023 Sep 20;14:1224221. doi: 10.3389/fmicb.2023.1224221. eCollection 2023.
3
Comparative Genome Analysis of Old World and New World TYLCV Reveals a Biasness toward Highly Variable Amino Acids in Coat Protein.
Plants (Basel). 2023 May 16;12(10):1995. doi: 10.3390/plants12101995.
4
Geminiviral betasatellites: critical viral ammunition to conquer plant immunity.
Arch Virol. 2023 Jun 30;168(7):196. doi: 10.1007/s00705-023-05776-9.
5
Impact of viral silencing suppressors on plant viral synergism: a global agro-economic concern.
Appl Microbiol Biotechnol. 2021 Aug;105(16-17):6301-6313. doi: 10.1007/s00253-021-11483-9. Epub 2021 Aug 23.
6
Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2.
Front Microbiol. 2021 Apr 9;12:645419. doi: 10.3389/fmicb.2021.645419. eCollection 2021.
7
Characterization of Pathogenicity-Associated V2 Protein of Tobacco Curly Shoot Virus.
Int J Mol Sci. 2021 Jan 18;22(2):923. doi: 10.3390/ijms22020923.
8
Superinfection by PHYVV Alters the Recovery Process in PepGMV-Infected Pepper Plants.
Viruses. 2020 Mar 5;12(3):286. doi: 10.3390/v12030286.
本文引用的文献
1
ICTV Virus Taxonomy Profile: Geminiviridae.
J Gen Virol. 2017 Feb;98(2):131-133. doi: 10.1099/jgv.0.000738.
2
Biogenesis, Function, and Applications of Virus-Derived Small RNAs in Plants.
Front Microbiol. 2015 Nov 9;6:1237. doi: 10.3389/fmicb.2015.01237. eCollection 2015.
3
Geminivirus-encoded TrAP suppressor inhibits the histone methyltransferase SUVH4/KYP to counter host defense.
Elife. 2015 Sep 7;4:e06671. doi: 10.7554/eLife.06671.
4
The Tomato yellow leaf curl virus (TYLCV) V2 protein inhibits enzymatic activity of the host papain-like cysteine protease CYP1.
Biochem Biophys Res Commun. 2015 May 8;460(3):525-9. doi: 10.1016/j.bbrc.2015.03.063. Epub 2015 Mar 19.
5
viral silencing suppressors: Tools forged to fine-tune host-pathogen coexistence.
Virology. 2015 May;479-480:85-103. doi: 10.1016/j.virol.2015.02.028. Epub 2015 Mar 9.
6
Identification of an RNA silencing suppressor encoded by a mastrevirus.
J Gen Virol. 2014 Sep;95(Pt 9):2082-2088. doi: 10.1099/vir.0.064246-0. Epub 2014 May 27.
7
Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression.
PLoS Pathog. 2014 Feb 6;10(2):e1003921. doi: 10.1371/journal.ppat.1003921. eCollection 2014 Feb.
8
V2 of tomato yellow leaf curl virus can suppress methylation-mediated transcriptional gene silencing in plants.
J Gen Virol. 2014 Jan;95(Pt 1):225-230. doi: 10.1099/vir.0.055798-0. Epub 2013 Nov 3.
9
Geminiviruses: masters at redirecting and reprogramming plant processes.
Nat Rev Microbiol. 2013 Nov;11(11):777-88. doi: 10.1038/nrmicro3117. Epub 2013 Oct 8.
10
Molecular identification of Ageratum enation virus, betasatellite and alphasatellite molecules isolated from yellow vein diseased Amaranthus cruentus in India.
Virus Genes. 2013 Dec;47(3):584-90. doi: 10.1007/s11262-013-0971-6. Epub 2013 Aug 21.
Zotero 插件