Yamasaki A, Rose G G, Pinero G J, Mahan C J
J Oral Pathol. 1987 Mar;16(3):129-34. doi: 10.1111/j.1600-0714.1987.tb01479.x.
Specimens from 2 cases of gingival hyperplasia resulting from the treatment with the immunosuppressant cyclosporin A (CSGH) and 4 cases of inflamed gingiva (non-CSGH) were examined by electron microscopy with particular interest in the fibroblasts. In general, the fibroblasts in CSGH revealed the ultrastructural characteristics of active protein synthesis and secretion and less cytotoxic or degenerative changes. Some fibroblasts in the CSGH (23.8%) displayed cytological modifications comparable to so-called myofibroblasts, i.e., microfilament bands with semi-periodic dense nodes, nuclear indentations, and basal-lamina associated, cell-to-stromal junctions. Conversely, 5.9% of the fibroblasts in the non-CSGH showed these modifications. The modified fibroblasts were found most predominantly in the transitional area between inflamed and fibrous connective tissues. From these findings, it is suggested that the myofibroblastic modification in CSGH is regarded as a common morphological sign in actively proliferating fibrous tissue and may participate in the host-tissue response to the plaque-associated irritants.
对2例因使用免疫抑制剂环孢素A导致牙龈增生（环孢素A所致牙龈增生，CSGH）和4例炎症性牙龈（非环孢素A所致牙龈增生，非CSGH）的标本进行了电子显微镜检查，特别关注成纤维细胞。总体而言，CSGH中的成纤维细胞显示出活跃蛋白质合成和分泌的超微结构特征，细胞毒性或退行性变化较少。CSGH中的一些成纤维细胞（23.8%）表现出与所谓肌成纤维细胞相当的细胞学改变，即具有半周期性致密结节的微丝带、核凹陷以及与基膜相关的细胞与基质连接。相反，非CSGH中的成纤维细胞有5.9%表现出这些改变。改良的成纤维细胞主要见于炎症性结缔组织和纤维性结缔组织之间的过渡区域。从这些发现来看，提示CSGH中的肌成纤维细胞改变被视为活跃增殖的纤维组织中的一种常见形态学标志，可能参与宿主组织对菌斑相关刺激物的反应。
