Chomette G, Auriol M, Szpirglas H, Ragot J, Thomas D, Cabrol C, Vaillant J M
Rev Stomatol Chir Maxillofac. 1986;87(5):287-93.
11 specimens were carried out in patients with idiopathic gingival hyperplasia (3 cases), gravidic hyperplasia (1 case), iatrogenic hyperplasia (5 cases after cyclosporin A administrated in patients with cardiac grafts, 2 cases after treatment by Adalat). By optic microscopy, the deep collagen base is thickened, associated sometimes to an inflammatory process. By histoenzymology, the fibroblasts have high activities of their oxidative enzymes and also of the enzymes of protein synthesis. The electron microscopy corroborates the numerous globular fibroblasts with well-developed rough endoplasmic reticulum. These results prove the main role of fibroblasts in these lesions and the etiopathogenesis of this hyperplasia is discussed.
对11例患者的标本进行了研究，其中特发性牙龈增生患者3例，妊娠性增生患者1例，医源性增生患者11例（心脏移植患者服用环孢素A后5例，服用硝苯地平治疗后2例）。光学显微镜检查显示，深层胶原基质增厚，有时与炎症过程相关。组织酶学检查显示，成纤维细胞的氧化酶和蛋白质合成酶活性较高。电子显微镜检查证实存在大量具有发达粗面内质网的球状成纤维细胞。这些结果证明了成纤维细胞在这些病变中的主要作用，并对这种增生的病因病机进行了讨论。
