The Danish Multiple Sclerosis Registry, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark/Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Mult Scler. 2020 Jul;26(8):902-911. doi: 10.1177/1352458519851245. Epub 2019 May 30.
A diagnosis of multiple sclerosis (MS) may impact the choice of parenthood.
To investigate the number of live births, abortions and ectopic pregnancies among persons with MS.
From the Danish Multiple Sclerosis Registry, we extracted data from all persons diagnosed with MS from 1960 to 1996 and matched each MS person with four reference persons. We used a negative binomial regression model for the live births and Poisson regression model for abortions and ectopic pregnancies. The total fertility rate (TFR) during 1960-2016 and the annual number of live births in the MS population were analysed.
Persons with MS had fewer children than reference persons. Fewer women with MS had elective abortions after diagnosis (incidence rate ratio (IRR) = 0.88; 95% confidence interval (CI) = 0.78-1.00) than reference persons. There was no difference regarding the number of elective abortions, spontaneous abortions or ectopic pregnancies after onset. The TFR was lower for women with MS than for reference persons, and the number of annual live births by MS persons increased during 1960-2016.
MS seems to considerably impact reproductive choices, especially after clinical diagnosis, resulting in the MS population having fewer children than the general population.
多发性硬化症 (MS) 的诊断可能会影响生育选择。
调查多发性硬化症患者的活产数、流产和异位妊娠。
我们从丹麦多发性硬化症登记处提取了 1960 年至 1996 年间所有诊断为 MS 的患者的数据，并将每位 MS 患者与四位对照者相匹配。我们使用负二项回归模型分析活产数，使用泊松回归模型分析流产和异位妊娠。分析了 1960 年至 2016 年的总生育率 (TFR) 和 MS 人群的年活产数。
MS 患者的子女数量少于对照者。与对照者相比，诊断后进行人工流产的 MS 患者较少（发病率比 (IRR) = 0.88；95%置信区间 (CI) = 0.78-1.00）。发病后，人工流产、自然流产或异位妊娠的数量没有差异。MS 患者的 TFR 低于对照者，并且 MS 患者的年活产数在 1960 年至 2016 年间增加。
MS 似乎会对生育选择产生重大影响，尤其是在临床诊断后，导致 MS 患者的子女数量少于一般人群。
