Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Department of Psychiatry, UCSF Weill Institute for Neurosciences.
Curr Opin Psychiatry. 2019 Sep;32(5):381-387. doi: 10.1097/YCO.0000000000000525.
Clinical, epidemiological, and biological evidence raises the possibility that serious mental disorders (SMDs) are associated with accelerated biological aging. To the extent this is true; SMDs should not simply be considered in terms of mental illness or brain dysfunction, but also as 'whole body' and multisystem illnesses, or else as conditions with significant somatic concomitants.
The concept of accelerated biological aging in SMDs is supported by reports of accelerated changes in certain biomarkers normally associated with the aging process.
We define and discuss several proposed biological aging markers that have been examined in SMDs, we review the most recent findings, and we conclude with opinions regarding the merits and meanings of these markers, their usefulness in understanding and treating SMDs, and remaining questions and future directions in this area of research.
临床、流行病学和生物学证据表明,严重精神障碍(SMD)与加速的生物衰老有关。如果这是真的;那么 SMD 不仅应被视为精神疾病或大脑功能障碍,还应被视为“全身”和多系统疾病,或者是具有重大躯体伴随的疾病。
SMD 中加速的生物衰老的概念得到了某些生物标志物的报告的支持,这些标志物通常与衰老过程有关,其变化是加速的。
我们定义和讨论了几种已在 SMD 中检查过的拟议生物衰老标志物,回顾了最新发现,并就这些标志物的优点和意义、它们在理解和治疗 SMD 中的用途以及该研究领域的遗留问题和未来方向发表了意见。