创伤应激与细胞加速衰老：从表观遗传学到心脏代谢疾病
Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease.
作者信息
Wolf Erika J, Morrison Filomene G
机构信息
National Center for PTSD, VA Boston Healthcare System, (116B-2), 150 South Huntington Ave, Boston, MA, 02130, USA.
Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
出版信息
Curr Psychiatry Rep. 2017 Aug 29;19(10):75. doi: 10.1007/s11920-017-0823-5.
Abstract
PURPOSE OF REVIEW
The aim of this paper is to review the recent literature on traumatic stress-related accelerated aging, including a focus on cellular mechanisms and biomarkers of cellular aging and on the clinical manifestations of accelerated biological aging.
RECENT FINDINGS
Multiple lines of research converge to suggest that PTSD is associated with accelerated aging in the epigenome, and the immune and inflammation systems, and this may be reflected in premature onset of cardiometabolic and cardiovascular disease. The current state of research paves the way for future work focused on identifying the peripheral and central biological mechanisms linking traumatic stress to accelerated biological aging and medical morbidity, with an emphasis on processes involved in inflammation, immune functioning, oxidative stress, autonomic arousal, and stress response. Ultimately, such work could help reduce the pace of biological aging and improve health and wellness.
摘要
综述目的
本文旨在回顾近期关于创伤应激相关加速衰老的文献，重点关注细胞衰老的细胞机制和生物标志物以及加速生物衰老的临床表现。
最新发现
多项研究表明，创伤后应激障碍（PTSD）与表观基因组、免疫和炎症系统的加速衰老有关，这可能反映在心脏代谢和心血管疾病的过早发生上。目前的研究状况为未来的工作铺平了道路，未来工作将聚焦于确定将创伤应激与加速生物衰老和医学发病联系起来的外周和中枢生物学机制，重点关注炎症、免疫功能、氧化应激、自主唤醒和应激反应所涉及的过程。最终，此类工作有助于减缓生物衰老速度，改善健康状况。
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本文引用的文献
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Psychoneuroendocrinology. 2018 Jun;92:123-134. doi: 10.1016/j.psyneuen.2017.12.007. Epub 2017 Dec 27.
2
Accelerated DNA Methylation Age: Associations With Posttraumatic Stress Disorder and Mortality.加速的 DNA 甲基化年龄：与创伤后应激障碍和死亡率的关联。
Psychosom Med. 2018 Jan;80(1):42-48. doi: 10.1097/PSY.0000000000000506.
3
Dementia Risk in Posttraumatic Stress Disorder: the Relevance of Sleep-Related Abnormalities in Brain Structure, Amyloid, and Inflammation.创伤后应激障碍与痴呆风险：脑结构、淀粉样蛋白和炎症相关的睡眠异常的相关性。
Curr Psychiatry Rep. 2017 Oct 16;19(11):89. doi: 10.1007/s11920-017-0835-1.
4
Oxidative Stress, Inflammation, and Neuroprogression in Chronic PTSD.慢性创伤后应激障碍中的氧化应激、炎症和神经进展。
Harv Rev Psychiatry. 2018 Mar/Apr;26(2):57-69. doi: 10.1097/HRP.0000000000000167.
5
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Biol Psychiatry. 2017 Dec 15;82(12):875-884. doi: 10.1016/j.biopsych.2017.06.020. Epub 2017 Jun 27.
6
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Am J Med Genet B Neuropsychiatr Genet. 2017 Sep;174(6):619-630. doi: 10.1002/ajmg.b.32568. Epub 2017 Jul 10.
7
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9
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