Department of General Practice, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Department of Cardiology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Clin Appl Thromb Hemost. 2021 Jan-Dec;27:1076029621999722. doi: 10.1177/1076029621999722.
We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients. The cross-sectional study included 459 patients with T2DM, the clinical and laboratory tests were performed, and all T2DM patients were separated into the 3 groups based on the tertile of serum adenosine deaminase levels. In the baseline data, the CAC score had statistically significant differences between the 3 groups (p < 0.001). Serum adenosine deaminase levels were positively correlated with CAC score in T2DM patients (r = 0.355, p < 0.001). The results of multiple linear regression analysis showed that serum adenosine deaminase was independent positively correlated with CAC score in T2DM patients (r = 0.255, p < 0.001). Receiver-operating characteristic curve analysis showed that area under curve was 0.750 to identify T2DM patients with CAC. Serum adenosine deaminase levels are correlated with CAC scores in T2DM patients, clinically, serum adenosine deaminase should be considered as an underlying marker to determine the severity of atherosclerosis in T2DM patients.
我们研究了血清腺苷脱氨酶与 2 型糖尿病（T2DM）患者冠状动脉钙化（CAC）之间的关系。这项横断面研究纳入了 459 例 T2DM 患者，进行了临床和实验室检查，并根据血清腺苷脱氨酶水平的三分位将所有 T2DM 患者分为 3 组。在基线数据中，3 组间 CAC 评分存在统计学差异（p<0.001）。血清腺苷脱氨酶水平与 T2DM 患者的 CAC 评分呈正相关（r=0.355，p<0.001）。多元线性回归分析结果显示，血清腺苷脱氨酶与 T2DM 患者的 CAC 评分呈独立正相关（r=0.255，p<0.001）。受试者工作特征曲线分析显示，曲线下面积为 0.750，可用于识别有 CAC 的 T2DM 患者。血清腺苷脱氨酶水平与 T2DM 患者的 CAC 评分相关，临床上应考虑血清腺苷脱氨酶作为确定 T2DM 患者动脉粥样硬化严重程度的潜在标志物。
