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一种用于高剂量水平 EBT3 Gafchromic 胶片读出的新方法。

A novel method for EBT3 Gafchromic films read-out at high dose levels.

机构信息

Optoelectronics Group - Department of Engineering, University of Sannio, I-82100 Benevento, Italy.

Optoelectronics Group - Department of Engineering, University of Sannio, I-82100 Benevento, Italy.

出版信息

Phys Med. 2019 May;61:77-84. doi: 10.1016/j.ejmp.2019.04.013. Epub 2019 May 3.

DOI:10.1016/j.ejmp.2019.04.013
PMID:31151583
Abstract

In this work, we report on a novel approach for measuring the dose absorbed by the EBT3 Gafchromic™ films exposed to 1 MeV electron beam and 250 kV X-rays in the range 0.5-100 Gy. Although EBT3 is specifically designed to obtain best performance for applications where the maximum dose is less than 10 Gy, there are certain clinical applications requiring dose ranges well above this value. In order to cover wider dose ranges, further models characterized by a thinner sensitive layer and/or different chemical composition have been released. Another method exploiting the three-channel flatbed scanner to delay the saturation point of EBT3 has been also reported. The technique proposed here, aimed at extending the sensitivity of the EBT3 film to high doses up to 100 Gy while ensuring a low dose uncertainty, is based on a broadband analysis of the absorption spectrum of the film in response to irradiation. By combining a wavelength-based approach with the monitoring of two characteristic peaks of the EBT3 absorption spectrum, we demonstrated the capability of measuring the dose in the range 0.5-100 Gy with an experimental uncertainty below 4% for doses lower than 5.52 Gy and below 2% for higher dose levels. Finally, through a dynamic fitting procedure integrating the two aforesaid approaches, a total uncertainty lower than 4%, including both the experimental and fitting errors, was achieved in the whole range 0.5-100 Gy. These results are promising in view of a potential application of this technique in the field of clinical dosimetry at high dose levels.

摘要

在这项工作中,我们报告了一种新的方法,用于测量 EBT3 Gafchromic™ 薄膜在 1 MeV 电子束和 250 kV X 射线照射下吸收的剂量,剂量范围为 0.5-100Gy。虽然 EBT3 专门设计用于在最大剂量小于 10Gy 的应用中获得最佳性能,但某些临床应用需要远远超过该值的剂量范围。为了覆盖更宽的剂量范围,已经发布了具有更薄敏感层和/或不同化学成分的进一步模型。还报道了另一种利用三通道平板扫描仪延迟 EBT3 饱和点的方法。这里提出的技术旨在将 EBT3 薄膜的灵敏度扩展到高达 100Gy 的高剂量,同时确保低剂量不确定度,该技术基于对薄膜在辐照下的吸收光谱进行宽带分析。通过结合基于波长的方法和监测 EBT3 吸收光谱的两个特征峰,我们证明了在剂量低于 5.52Gy 时,测量 0.5-100Gy 范围内剂量的能力,实验不确定度低于 4%,在更高剂量水平下,实验不确定度低于 2%。最后,通过整合上述两种方法的动态拟合程序,在 0.5-100Gy 的整个范围内实现了低于 4%的总不确定度,包括实验和拟合误差。这些结果对于该技术在高剂量临床剂量学领域的潜在应用是有希望的。

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