Jaccard Maud, Petersson Kristoffer, Buchillier Thierry, Germond Jean-François, Durán Maria Teresa, Vozenin Marie-Catherine, Bourhis Jean, Bochud François O, Bailat Claude
Institute of Radiation Physics (IRA), Lausanne University Hospital, Lausanne, Switzerland.
Department of Radiation Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Med Phys. 2017 Feb;44(2):725-735. doi: 10.1002/mp.12066. Epub 2017 Feb 8.
The aim of this study was to assess the suitability of Gafchromic EBT3 films for reference dose measurements in the beam of a prototype high dose-per-pulse linear accelerator (linac), capable of delivering electron beams with a mean dose-rate (Ḋ ) ranging from 0.07 to 3000 Gy/s and a dose-rate in pulse (Ḋ ) of up to 8 × 10 Gy/s. To do this, we evaluated the overall uncertainties in EBT3 film dosimetry as well as the energy and dose-rate dependence of their response.
Our dosimetric system was composed of EBT3 Gafchromic films in combination with a flatbed scanner and was calibrated against an ionization chamber traceable to primary standard. All sources of uncertainties in EBT3 dosimetry were carefully analyzed using irradiations at a clinical radiotherapy linac. Energy dependence was investigated with the same machine by acquiring and comparing calibration curves for three different beam energies (4, 8 and 12 MeV), for doses between 0.25 and 30 Gy. Ḋ dependence was studied at the clinical linac by changing the pulse repetition frequency (f) of the beam in order to vary Ḋ between 0.55 and 4.40 Gy/min, while Ḋ dependence was probed at the prototype machine for Ḋ ranging from 7 × 10 to 8 × 10 Gy/s. Ḋ dependence was first determined by studying the correlation between the dose measured by films and the charge of electrons measured at the exit of the machine by an induction torus. Furthermore, we compared doses from the films to independently calibrated thermo-luminescent dosimeters (TLD) that have been reported as being dose-rate independent up to such high dose-rates.
We report that uncertainty below 4% (k = 2) can be achieved in the dose range between 3 and 17 Gy. Results also demonstrated that EBT3 films did not display any detectable energy dependence for electron beam energies between 4 and 12 MeV. No Ḋ dependence was found either. In addition, we obtained excellent consistency between films and TLDs over the entire Ḋ range attainable at the prototype linac confirming the absence of any dose-rate dependence within the investigated range (7 × 10 to 8 × 10 Gy/s). This aspect was further corroborated by the linear relationship between the dose-per-pulse (D ) measured by films and the charge per pulse (C ) measured at the prototype linac exit.
Our study shows that the use of EBT3 Gafchromic films can be extended to reference dosimetry in pulsed electron beams with a very high dose rate. The measurement results are associated with an overall uncertainty below 4% (k = 2) and are dose-rate and energy independent.
本研究的目的是评估Gafchromic EBT3薄膜在一台原型高剂量率脉冲直线加速器(直线加速器)射束中进行参考剂量测量的适用性,该直线加速器能够产生平均剂量率(Ḋ)范围为0.07至3000 Gy/s且脉冲剂量率(Ḋ)高达8×10 Gy/s的电子束。为此,我们评估了EBT3薄膜剂量测定中的总体不确定性及其响应的能量和剂量率依赖性。
我们的剂量测定系统由EBT3 Gafchromic薄膜与平板扫描仪组成,并针对可溯源至原级标准的电离室进行校准。使用临床放射治疗直线加速器进行辐照,仔细分析了EBT3剂量测定中所有不确定性来源。通过获取并比较三种不同束能量(4、8和12 MeV)、剂量在0.25至30 Gy之间的校准曲线,利用同一台机器研究能量依赖性。在临床直线加速器上通过改变束的脉冲重复频率(f)来研究Ḋ依赖性,以便使Ḋ在0.55至4.40 Gy/min之间变化,而在原型机器上针对Ḋ范围为7×10至8×10 Gy/s探测Ḋ依赖性。首先通过研究薄膜测量的剂量与机器出口处感应环测量的电子电荷量之间的相关性来确定Ḋ依赖性。此外,我们将薄膜的剂量与独立校准的热释光剂量计(TLD)的剂量进行比较,据报道TLD在高达如此高剂量率时与剂量率无关。
我们报告在3至17 Gy的剂量范围内可实现低于4%(k = 2)的不确定性。结果还表明,对于4至12 MeV的电子束能量,EBT3薄膜未显示出任何可检测到的能量依赖性。也未发现Ḋ依赖性。此外,在原型直线加速器可达到的整个Ḋ范围内,我们在薄膜和TLD之间获得了极好的一致性,证实了在所研究的范围(7×10至8×10 Gy/s)内不存在任何剂量率依赖性。薄膜测量的每脉冲剂量(D)与原型直线加速器出口处测量的每脉冲电荷量(C)之间的线性关系进一步证实了这一点。
我们的研究表明,EBT3 Gafchromic薄膜的使用可扩展到非常高剂量率的脉冲电子束中的参考剂量测定。测量结果的总体不确定性低于4%(k = 2),且与剂量率和能量无关。