Department of Stem Cell Sciences, Graduate School of Health Sciences, Center for Stem Cell Research and Development, Hacettepe University, Sihhiye, 06100, Ankara, Turkey.
Cytokine Growth Factor Rev. 2019 Dec;50:13-18. doi: 10.1016/j.cytogfr.2019.05.010. Epub 2019 May 21.
Beyond their essential role in leukocyte homing in the context of inflammation, chemokines orchestrate the host response to cancer progression. Chemokines are key accelerators in the amplification of inflammatory signals and metastasis in the distal zone of tumors, indicating possible immune editing of tumor cells in the microenvironment. This review summarizes the main macrophage-attracting chemokines secreted from cancer cells and how these mediators can be targeted to improve cancer immunotherapy in multiple cancer types.
除了在炎症背景下白细胞归巢中发挥重要作用外，趋化因子还协调宿主对癌症进展的反应。趋化因子是肿瘤远端区域炎症信号放大和转移的关键加速剂，表明肿瘤细胞在微环境中可能发生免疫编辑。本文综述了癌细胞分泌的主要巨噬细胞趋化因子，以及如何针对这些介质来改善多种癌症类型的癌症免疫治疗。
