Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA, USA.
Department of Nursing, College of Nursing, Korea University, Seoul, Republic of Korea.
Nutr Metab Cardiovasc Dis. 2019 Aug;29(8):837-846. doi: 10.1016/j.numecd.2019.04.011. Epub 2019 May 7.
Few studies have examined the association of long-chain n-3 polyunsaturated fatty acids (LCn-3PUFAs) with the measures of atherosclerosis in the general population. This study aimed to examine the relationship of total LCn-3PUFAs, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) with aortic calcification.
In a multiethnic population-based cross-sectional study of 998 asymptomatic men aged 40-49 years (300 US-White, 101 US-Black, 287 Japanese American, and 310 Japanese in Japan), we examined the relationship of serum LCn-3PUFAs to aortic calcification (measured by electron-beam computed tomography and quantified using the Agatston method) using Tobit regression and ordinal logistic regression after adjusting for potential confounders. Overall 56.5% participants had an aortic calcification score (AoCaS) > 0. The means (SD) of total LCn-3PUFAs, EPA, and DHA were 5.8% (3.3%), 1.4% (1.3%), and 3.7% (2.1%), respectively. In multivariable-adjusted Tobit regression, a 1-SD increase in total LCn-3PUFAs, EPA, and DHA was associated with 29% (95% CI = 0.51, 1.00), 9% (95% CI = 0.68, 1.23), and 35% (95% CI = 0.46, 0.91) lower AoCaS, respectively. Results were similar in ordinal logistic regression analysis. There was no significant interaction between race/ethnicity and total LCn-3PUFAs, EPA or DHA on aortic calcification.
This study showed the significant inverse association of LCn-3PUFAs with aortic calcification independent of conventional cardiovascular risk factors among men in the general population. This association appeared to be driven by DHA but not EPA.
很少有研究探讨长链 n-3 多不饱和脂肪酸 (LCn-3PUFAs) 与普通人群动脉粥样硬化指标之间的关系。本研究旨在探讨总 LCn-3PUFAs、二十碳五烯酸 (EPA) 和二十二碳六烯酸 (DHA) 与主动脉钙化的关系。
在一项针对 998 名 40-49 岁无症状男性（300 名美国白人、101 名美国黑人、287 名日裔美国人和 310 名日本籍日本人）的多民族基于人群的横断面研究中，我们使用 Tobit 回归和有序逻辑回归在调整了潜在混杂因素后，检查了血清 LCn-3PUFAs 与主动脉钙化（通过电子束计算机断层扫描测量并用 Agatston 方法量化）之间的关系。总体而言，56.5%的参与者的主动脉钙化评分（AoCaS）>0。总 LCn-3PUFAs、EPA 和 DHA 的平均值（标准差）分别为 5.8%（3.3%）、1.4%（1.3%）和 3.7%（2.1%）。在多变量调整的 Tobit 回归中，总 LCn-3PUFAs、EPA 和 DHA 每增加 1 个标准差，AoCaS 分别降低 29%（95%可信区间为 0.51，1.00）、9%（95%可信区间为 0.68，1.23）和 35%（95%可信区间为 0.46，0.91）。有序逻辑回归分析的结果相似。种族/民族与总 LCn-3PUFAs、EPA 或 DHA 之间在主动脉钙化方面没有显著的交互作用。
本研究表明，LCn-3PUFAs 与普通人群男性的主动脉钙化呈显著负相关，独立于传统心血管危险因素。这种关联似乎是由 DHA 驱动的，而不是 EPA。
