韩国人、白人和日裔美国人中总海洋脂肪酸、二十碳五烯酸和二十二碳六烯酸与主动脉僵硬度的关联。
Association of total marine fatty acids, eicosapentaenoic and docosahexaenoic acids, with aortic stiffness in Koreans, whites, and Japanese Americans.
作者信息
Sekikawa Akira, Shin Chol, Masaki Kamal H, Barinas-Mitchell Emma J M, Hirooka Nobutaka, Willcox Bradley J, Choo Jina, White Jessica, Evans Rhobert W, Fujiyoshi Akira, Okamura Tomonori, Miura Katsuyuki, Muldoon Matthew F, Ueshima Hirotsugu, Kuller Lewis H, Sutton-Tyrrell Kim
机构信息
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania;
Department of Internal Medicine, Korea University Medical Center Ansan Hospital, Ansan-City, South Korea;
出版信息
Am J Hypertens. 2013 Nov;26(11):1321-7. doi: 10.1093/ajh/hpt107. Epub 2013 Jul 2.
BACKGROUND
Few previous studies have reported the association of aortic stiffness with marine n-3 fatty acids (Fas) in the general population. The aim of this study was to determine the combined and independent associations of 2 major marine n-3 FAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), with aortic stiffness evaluated using carotid-femoral pulse wave velocity (cfPWV) in Korean, white, and Japanese American men.
METHODS
A population-based sample of 851 middle-aged men (299 Koreans, 266 whites, and 286 Japanese Americans) was examined for cfPWV during 2002-2006. Serum FAs, including EPA and DHA, were measured as a percentage of total FAs using gas chromatography. Multiple regression analysis was used to examine the association of EPA and DHA with cfPWV after adjusting for blood pressure and other confounders.
RESULTS
Mean EPA and DHA levels were 1.9 (SD = 1.0) and 4.8 (SD = 1.4) for Koreans, 0.8 (SD = 0.6) and 2.4 (SD = 1.2) for whites, and 1.0 (SD = 1.0) and 3.2 (SD = 1.4) for Japanese Americans. Both EPA and DHA were significantly higher in Koreans than in the other 2 groups (P < 0.01). Multiple regression analyses in Koreans showed that cfPWV had a significant inverse association with total marine n-3 FAs and with EPA alone after adjusting for blood pressure and other potential confounders. In contrast, there was no significant association of cfPWV with DHA. Whites and Japanese Americans did not show any significant associations of cfPWV with total marine n-3 FAs, EPA, or DHA.
CONCLUSIONS
High levels of EPA observed in Koreans have an inverse association with aortic stiffness.
背景
此前很少有研究报道普通人群中主动脉僵硬度与海洋n-3脂肪酸（Fas）之间的关联。本研究的目的是确定两种主要的海洋n-3脂肪酸，即二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），与使用颈动脉-股动脉脉搏波速度（cfPWV）评估的主动脉僵硬度之间的联合关联和独立关联，研究对象为韩国、白种和日裔美国男性。
方法
在2002年至2006年期间，对851名中年男性（299名韩国人、266名白种人、286名日裔美国人）进行基于人群的样本检测，测量cfPWV。使用气相色谱法测量血清脂肪酸，包括EPA和DHA，以总脂肪酸的百分比表示。在调整血压和其他混杂因素后，使用多元回归分析来检验EPA和DHA与cfPWV之间的关联。
结果
韩国人的平均EPA和DHA水平分别为1.9（标准差=1.0）和4.8（标准差=1.4），白种人分别为0.8（标准差=0.6）和2.4（标准差=1.2），日裔美国人分别为1.0（标准差=1.0）和3.2（标准差=1.4）。韩国人的EPA和DHA水平均显著高于其他两组（P<0.01）。对韩国人的多元回归分析表明，在调整血压和其他潜在混杂因素后，cfPWV与总海洋n-3脂肪酸以及单独的EPA呈显著负相关。相比之下，cfPWV与DHA没有显著关联。白种人和日裔美国人的cfPWV与总海洋n-3脂肪酸、EPA或DHA均未显示出任何显著关联。
结论
在韩国人中观察到的高水平EPA与主动脉僵硬度呈负相关。
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