偏侧味觉障碍、幻嗅与呼吸骤停：1例伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CLIPPERS）病例
Hemidysgeusia, phantosmia and respiratory arrest: a case of CLIPPERS.
作者信息
Nguyen Peter Baoviet, Prentice David, Brazel Robert, Leong Wai Kuen
机构信息
Department of Neurology, Royal Perth Hospital, Perth, Western Australia, Australia.
Perron Institute, Queen Elizabeth II Medical Centre, Nedlands, Western Australia, Australia.
出版信息
BMJ Case Rep. 2019 May 30;12(5):e230094. doi: 10.1136/bcr-2019-230094.
Abstract
A 56-year-old man presented with a relapse of likely chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after a reduction of steroid dose. MRI demonstrated new perivascular FLuid-Attenuated Inversion Recovery (FLAIR) signal hyperintensity involving the dorsal pontomedullary junction and progressing inferiorly into the dorsal medulla oblongata. His admission to hospital was complicated by a respiratory arrest.
摘要
一名56岁男性在减少类固醇剂量后，出现了可能的类固醇反应性桥脑周围血管强化慢性淋巴细胞性炎症复发（CLIPPERS）。磁共振成像（MRI）显示新的血管周围液体衰减反转恢复序列（FLAIR）信号高增强，累及桥延髓背侧交界处，并向下延伸至延髓背侧。他入院时并发了呼吸骤停。
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J Intensive Care Soc. 2018 May;19(2):167-170. doi: 10.1177/1751143717719644. Epub 2017 Jul 17.
2
A cerebral phenotype of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report and review of the literature.类固醇反应性伴有桥脑血管周围强化的慢性淋巴细胞炎症性脑病：病例报告及文献复习。
Mult Scler Relat Disord. 2018 Feb;20:159-163. doi: 10.1016/j.msard.2018.01.017. Epub 2018 Jan 31.
3
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