Woolf A D, Wakerley G, Wallington T B, Scott D G, Dieppe P A
Ann Rheum Dis. 1987 Jun;46(6):441-7. doi: 10.1136/ard.46.6.441.
Factor VIII related antigen, an endothelial cell product, was markedly raised in systemic necrotising arteritis, reflecting disease activity, but was not raised in active cutaneous vasculitis. In rheumatoid arthritis high levels were only found in systemic vasculitis or Felty's syndrome, but in other connective tissue diseases increased levels were more frequently detected and usually related to disease activity. It did not correlate with C reactive protein. It was also raised in non-inflammatory peripheral vascular disease and after surgery and was not specific for vasculitic endothelial damage. Factor VIII related antigen may be useful in identifying and monitoring systemic necrotising and large vessel arteritis.
血管内皮细胞产生的因子VIII相关抗原在系统性坏死性动脉炎中显著升高，反映疾病活动，但在活动性皮肤血管炎中未升高。在类风湿关节炎中，高水平仅见于系统性血管炎或费尔蒂综合征，但在其他结缔组织病中更常检测到水平升高，且通常与疾病活动相关。它与C反应蛋白不相关。在非炎性外周血管疾病及手术后它也会升高，并非血管炎性内皮损伤所特有。因子VIII相关抗原在识别和监测系统性坏死性及大血管动脉炎方面可能有用。
