Tse W Y, Cockwell P, Savage C O
Department of Medicine, CCRIS, Medical School, University of Birmingham, UK.
Postgrad Med J. 1998 Jan;74(867):1-6. doi: 10.1136/pgmj.74.867.1.
The systemic vasculitides are a group of inflammatory disorders characterised by relapses and remission. Before the introduction of immunosuppressive drugs, mortality was unacceptably high. Immunosuppressive therapy has had a therapeutic impact, but at the cost of increased risk of infection and other adverse effects. Differentiating infection from active disease can be difficult, and the inappropriate prescription of immunosuppressive drugs can be fatal. Hence disease indices which can aid physicians to identify the active phase of disease and enable early treatment, will be valuable in the management of this group of disorders.
系统性血管炎是一组以复发和缓解为特征的炎症性疾病。在免疫抑制药物引入之前，死亡率高得令人难以接受。免疫抑制疗法产生了治疗效果，但代价是感染风险和其他不良反应增加。区分感染与疾病活动可能很困难，不适当的免疫抑制药物处方可能是致命的。因此，能够帮助医生识别疾病活动期并实现早期治疗的疾病指标，在这组疾病的管理中将具有重要价值。
