Department of Biomedicine, University of Basel, CH-4031 Basel, Switzerland.
Unité de Recherche Clinique, Centre Hospitalier de Valenciennes, 59322 Valenciennes, France.
J Immunol. 2019 Jul 15;203(2):544-556. doi: 10.4049/jimmunol.1800938. Epub 2019 May 31.
The nucleotide-binding oligomerization domain (NOD)-like receptors belong to the family of pattern recognition receptors (PRRs). NOD-like receptors play a role in regulation of innate immune response by recognition of both pathogen-associated molecular patterns that are engulfed during phagocytic process and danger-associated molecular patterns that are mainly byproducts of cell stress mediated response. NOD-like family pyrin domain containing 6 (NLRP6) is one of the 14 pyrin domain-containing receptors. NLRP6 is highly expressed by epithelial and goblet cells to regulate epithelial renewal and mucus production in mice and humans, but its function in T cells is rather unknown. Increased caspase-1 activation and cell death were observed in mouse -deficient T cells following adoptive transfer into -deficient mice, indicating that deficiency in CD4 T cells led to decreased survival.
核苷酸结合寡聚化结构域（NOD）样受体属于模式识别受体（PRRs）家族。NOD 样受体通过吞噬过程中吞噬的病原体相关分子模式和主要由细胞应激介导反应的副产物的危险相关分子模式的识别，在先天免疫反应的调节中发挥作用。NOD 样家族含吡喃结构域蛋白 6（NLRP6）是 14 个含吡喃结构域受体之一。NLRP6 在小鼠和人类的上皮细胞和杯状细胞中高表达，以调节上皮细胞更新和黏液产生，但它在 T 细胞中的功能尚不清楚。在将缺乏的 T 细胞过继转移到缺乏的小鼠中后，观察到小鼠缺陷 T 细胞中 caspase-1 激活和细胞死亡增加，表明 CD4 T 细胞中的缺陷导致存活率降低。
