Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, 76107, USA.
Geroscience. 2019 Jun;41(3):275-284. doi: 10.1007/s11357-019-00075-1. Epub 2019 May 31.
Aging is a fundamental biological process accompanied by a general decline in tissue function and an increased risk for age-related disease. The risk for cardiovascular, stroke, cancer, and neurodegenerative diseases significantly increases with aging, especially in people aged 60 years and older in the USA. Although the cellular and molecular mechanisms underlying aging and age-related disease are beginning to be unraveled, the role of the systemic milieu remains unknown. Recent studies have shown that systemic factors in young blood can revise age-related impairments and extend organismal lifespan, suggesting that the systemic milieu contains pro-aging and rejuvenating factors that play a critical role in the health and aging phenotype. In this review, we summarize the current knowledge of systemic milieu changes during the aging process and its link to age-related deterioration.
衰老是一个伴随组织功能普遍下降和与年龄相关疾病风险增加的基本生物学过程。心血管疾病、中风、癌症和神经退行性疾病的风险随着年龄的增长而显著增加，尤其是在美国 60 岁及以上的人群中。尽管衰老和与年龄相关疾病的细胞和分子机制开始被揭示，但系统环境的作用仍然未知。最近的研究表明，年轻血液中的系统因素可以修正与年龄相关的损伤，并延长生物体的寿命，这表明系统环境中含有促进衰老和恢复活力的因素，这些因素在健康和衰老表型中起着关键作用。在这篇综述中，我们总结了衰老过程中系统环境变化及其与与年龄相关的恶化的关联的现有知识。
