Blanc Mathieu, David Fabrice P A, van der Goot F Gisou
Global Health Institute, School of Life Sciences, EPFL, Lausanne, Switzerland.
Global Health Institute, Gene Expression Core Facility, SV-IT, School of Life Sciences, EPFL, Lausanne, Switzerland.
Methods Mol Biol. 2019;2009:203-214. doi: 10.1007/978-1-4939-9532-5_16.
Protein S-palmitoylation is increasingly recognized as an important posttranslational modification, present in all eukaryotic organisms, involved in the regulation of many biological processes. The SwissPalm database centralizes the large and increasing number of published palmitoyl-proteome datasets, provides tools to compare them, and includes curated data from the literature on the identification and analysis of palmitoylated proteins. SwissPalm 2 provides an updated version, with 38 palmitoyl-proteomes at the time of release, from 17 different species, and new features such as the inclusion of orthologs.
蛋白质S-棕榈酰化作为一种重要的翻译后修饰，在所有真核生物中都存在，参与许多生物过程的调节，这一点日益得到认可。SwissPalm数据库集中了大量且不断增加的已发表的棕榈酰化蛋白质组数据集，提供了比较这些数据集的工具，还包括来自文献中关于棕榈酰化蛋白质鉴定和分析的精选数据。SwissPalm 2提供了一个更新版本，发布时包含来自17个不同物种的38个棕榈酰化蛋白质组，以及诸如纳入直系同源物等新功能。
