School of Materials Science and Engineering, Sichuan University, Chengdu, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
J Biomed Mater Res A. 2019 Oct;107(10):2296-2309. doi: 10.1002/jbm.a.36738. Epub 2019 Jun 13.
Nanoscale hydroxyapatite (HAp) is an optimal candidate material in biomedical area for its good biocompatibility and bioactivity. In this study, HAp nanorods are prepared via hydrothermal method and combined with monolayered graphene oxide (GO). The obtained HAp@GO with excellent biocompatibility is revealed to have high drug loading capacity (698.7 μg/mg) for anticancer drug doxorubicin (DOX) and efficient photothermal conversion property. And the drug release property of DOX loaded HAp@GO (HAp@GO-DOX) is demonstrated to be controlled by pH and near-infrared light, which is favorable for cancer therapy. in vitro studies on cancer therapy demonstrate that the combined treatment, compared with either chemotherapy or photothermal therapy alone, has better synergistic therapeutic effect. These findings prove the great potential application of the nanocomposites for cancer therapy.
纳米级羟基磷灰石（HAp）因其良好的生物相容性和生物活性，成为生物医学领域的理想候选材料。本研究采用水热法制备了 HAp 纳米棒，并将其与单层氧化石墨烯（GO）结合。所得具有优异生物相容性的 HAp@GO 具有高载药量（698.7μg/mg）的抗癌药物阿霉素（DOX）和高效的光热转换性能。并证明负载 DOX 的 HAp@GO（HAp@GO-DOX）的药物释放性能可通过 pH 值和近红外光进行控制，有利于癌症治疗。癌症治疗的体外研究表明，与单独化疗或光热治疗相比，联合治疗具有更好的协同治疗效果。这些发现证明了该纳米复合材料在癌症治疗方面具有巨大的应用潜力。
