Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Air Pollution and Respiratory Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Biochim Biophys Acta Rev Cancer. 2019 Aug;1872(1):60-65. doi: 10.1016/j.bbcan.2019.05.008. Epub 2019 May 29.
Hepatocellular carcinoma (HCC), the most common form of liver cancer, represents a health problem in hepatic viruses-eradicating era because obesity, type 2 diabetes, and nonalcoholic steatohepatitis (NASH) are considered emerging pathogenic factors. Metabolic disorders underpin mitotic errors that lead to numerical and structural chromosome aberrations in a significant proportion of cell divisions. Here, we review that genomically unstable HCCs show evidence for a paradoxically DNA damage response (DDR) which leads to ongoing chromosome segregation errors. The understanding of DDR induced by defective mitoses is crucial to our ability to develop or improve liver cancer therapeutic strategies.
肝细胞癌（HCC）是最常见的肝癌形式，在肝病毒消除时代，它是一个健康问题，因为肥胖、2 型糖尿病和非酒精性脂肪性肝炎（NASH）被认为是新出现的致病因素。代谢紊乱导致有丝分裂错误，从而导致相当一部分细胞分裂中出现染色体数目和结构的畸变。在这里，我们回顾了基因组不稳定的 HCC 表现出一种矛盾的 DNA 损伤反应（DDR）的证据，这导致了持续的染色体分离错误。对有缺陷的有丝分裂引起的 DDR 的理解对于我们开发或改进肝癌治疗策略的能力至关重要。
