School of Medicine and Dentistry in Zabrze, Department of Internal Diseases, Angiology and Physical Medicine, Center for Laser Diagnostics and Therapy, Medical University of Silesia in Katowice, 15 Batory St., 41-902 Bytom, Poland; Urovita- Silesian Center of Urology, 11 Strzelców Bytomskich St., 41-500 Chorzów, Poland.
Department of Photomedicine and Physical Chemistry, Faculty of Medicine, University of Rzeszów, Tadeusza Rejtana Avenue 16 C, 35-310 Rzeszów, Poland.
Photodiagnosis Photodyn Ther. 2019 Sep;27:141-148. doi: 10.1016/j.pdpdt.2019.05.036. Epub 2019 May 29.
Bladder cancer is one of the most common Genito-urinary malignant tumors in humans. Improved diagnostic and therapeutic methods that aim to reduce rates of recurrence and progression of bladder cancer are needed. In current publications, one can find information on such methods as Raman spectroscopy, ultraviolet autofluorescence microscopy, confocal laser endoscopy, photoacoustic imaging, molecular imaging, multi-photon microscopy and many other new diagnostic techniques. These methods do not show significant adverse effects and are procedures well tolerated by patients as they use mostly physical phenomena that are neutral towards the human body. This review highlights the techniques of autofluorescence (AF) or laser induced fluorescence (LIF) and photodynamic diagnostics (PDD) which have been widely clinically studied for many years as a complement to cystoscopy. These methods can be performed during standard cystoscopy and they can be used in routine practice. This review shows that Autofluorescent and Photodynamic diagnostics are effective and have great potential in enhancing the diagnosis of bladder cancer. However, more research should be performed to help realize their full potential.
膀胱癌是人类最常见的泌尿生殖系统恶性肿瘤之一。需要改进旨在降低膀胱癌复发和进展率的诊断和治疗方法。在目前的出版物中，可以找到有关拉曼光谱、紫外线自发荧光显微镜、共焦激光内窥镜、光声成像、分子成像、多光子显微镜和许多其他新诊断技术等方法的信息。这些方法没有显示出明显的不良反应，并且由于它们主要使用对人体中性的物理现象，因此患者可以很好地耐受这些程序。本文综述了自发荧光 (AF) 或激光诱导荧光 (LIF) 和光动力诊断 (PDD) 技术，这些技术多年来作为膀胱镜检查的补充已广泛在临床上进行了研究。这些方法可以在标准膀胱镜检查期间进行，并且可以在常规实践中使用。本文综述表明，自发荧光和光动力诊断在增强膀胱癌的诊断方面是有效且有很大潜力的。然而，应该进行更多的研究来帮助充分发挥其潜力。
