Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Epithelial Polarity and Cell Division group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.
Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal; Epithelial Polarity and Cell Division group, Instituto de Investigação e Inovação em Saúde (i3S), Universidade do Porto, Porto, Portugal.
Curr Opin Cell Biol. 2019 Oct;60:75-83. doi: 10.1016/j.ceb.2019.04.006. Epub 2019 May 27.
Epithelial cell division is essential to shape developing tissues and for the homeostasis of adult organs. However, the mechanical and biochemical reorganization of dividing cells represents a major challenge to the integrity and architecture of the epithelial barrier. Here, we portray recent findings from a variety of model organisms that revealed how apical-basal polarity and intercellular adhesion are modulated during cell division to maintain a permeability barrier and to transmit epithelial organization to daughter cells. This demands not only that dividing and neighboring cells remodel their adhesion and contractility, but also cell cycle-dependent regulation of apical-basal polarity in the dividing cell. Additionally, mitotic structures, such as the midbody, provide spatial cues to enforce epithelial cell organization.
上皮细胞分裂对于塑造发育中的组织和维持成年器官的稳态至关重要。然而，分裂细胞的力学和生化重排对上皮屏障的完整性和结构构成了重大挑战。在这里，我们描绘了来自各种模式生物的最新发现，这些发现揭示了细胞分裂过程中如何调节顶端-基底极性和细胞间黏附，以维持渗透性屏障，并将上皮组织传递给子细胞。这不仅要求分裂细胞和相邻细胞重塑它们的黏附和收缩性，还要求分裂细胞中细胞周期依赖性的顶端-基底极性调节。此外，有丝分裂结构，如中间体，提供空间线索来强制实施上皮细胞组织。
