Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai 201615, China.
Trends Cell Biol. 2019 Aug;29(8):623-634. doi: 10.1016/j.tcb.2019.05.001. Epub 2019 May 29.
Cancer heterogeneity has long been recognized as an important clinical determinant of patient outcomes and, thus, many new cancer treatments have been designed to target these different cells. Despite the short-term achievements of current therapies, including chemotherapy, antiangiogenesis therapy, radiotherapy, and immunotherapy, the long-term success of cancer regression remains poor. Therefore, researchers have investigated a new property, cellular reprogramming, in cancer that not only contributes to the classic hallmarks of cancer, but also suggests that cancer is a dynamic event rather than a static cellular entity. Here, we discuss the mechanisms by which the cellular reprogramming of cancer cells can explain some of the phenotypic and functional heterogeneity observed among cancer cells.
癌症异质性长期以来一直被认为是影响患者预后的重要临床决定因素，因此，许多新的癌症治疗方法被设计用于靶向这些不同的细胞。尽管目前的治疗方法（包括化疗、抗血管生成治疗、放疗和免疫治疗）取得了短期的成效，但癌症的长期消退仍然效果不佳。因此，研究人员研究了癌症中的一个新特性——细胞重编程，它不仅有助于解释癌症的经典特征，还表明癌症是一个动态事件，而不是一个静态的细胞实体。在这里，我们讨论了癌细胞的细胞重编程如何能够解释在癌细胞中观察到的一些表型和功能异质性的机制。
