慢性阻塞性肺疾病的临床流行病学：COPDGene 研究 10 年的见解。
Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.
机构信息
Division of Pulmonary Diseases and Critical Care, UT Health San Antonio, and South Texas Veterans Health System, San Antonio, TX.
Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL.
出版信息
Chest. 2019 Aug;156(2):228-238. doi: 10.1016/j.chest.2019.04.135. Epub 2019 May 30.
Abstract
The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and biomarker profiling. The objective of this review was to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, sex, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma/COPD overlap.
摘要
COPD（COPDGene）研究的遗传流行病学是一项非介入性、多中心、纵向分析超过 10000 名受试者的研究，包括有≥10 包年吸烟史的 COPD 患者和无 COPD 患者以及健康从不吸烟的人群。目的是描述与疾病相关的表型，并探讨与易感基因的关联。使用全面的症状和合并症问卷、肺量测定、胸部 CT 扫描以及遗传和生物标志物分析对受试者进行了广泛的表型分析。本文综述了 COPDGene 研究的前 10 年中 COPD 临床流行病学的主要进展。我们强调了年龄、性别和种族对 COPD 自然史的影响，以及合并症、慢性支气管炎、加重和哮喘/COPD 重叠的影响。
相似文献
1
Clinical Epidemiology of COPD: Insights From 10 Years of the COPDGene Study.慢性阻塞性肺疾病的临床流行病学：COPDGene 研究 10 年的见解。
Chest. 2019 Aug;156(2):228-238. doi: 10.1016/j.chest.2019.04.135. Epub 2019 May 30.
2
Clinical Phenotypes of Atopy and Asthma in COPD: A Meta-analysis of SPIROMICS and COPDGene.慢性阻塞性肺疾病（COPD）中特应性和哮喘的临床表型：SPIROMICS和COPDGene的荟萃分析
Chest. 2020 Dec;158(6):2333-2345. doi: 10.1016/j.chest.2020.04.069. Epub 2020 May 23.
3
Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study.儿童肺炎增加慢性阻塞性肺疾病风险：慢性阻塞性肺疾病基因研究
Respir Res. 2015 Sep 21;16(1):115. doi: 10.1186/s12931-015-0273-8.
4
Genetic epidemiology of COPD (COPDGene) study design.COPD（COPDGene）遗传流行病学研究设计。
COPD. 2010 Feb;7(1):32-43. doi: 10.3109/15412550903499522.
5
Chronic Obstructive Pulmonary Disease Exacerbations Increase the Risk of Subsequent Cardiovascular Events: A Longitudinal Analysis of the COPDGene Study.慢性阻塞性肺疾病加重增加后续心血管事件风险：COPDGene 研究的纵向分析。
J Am Heart Assoc. 2024 Jun 4;13(11):e033882. doi: 10.1161/JAHA.123.033882. Epub 2024 May 31.
6
Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.慢性阻塞性肺疾病病例和对照者中每日吸烟量的常见和罕见变异基因关联分析。
Nicotine Tob Res. 2019 May 21;21(6):714-722. doi: 10.1093/ntr/nty095.
7
Epidemiology, radiology, and genetics of nicotine dependence in COPD.COPD 中尼古丁依赖的流行病学、影像学和遗传学。
Respir Res. 2011 Jan 13;12(1):9. doi: 10.1186/1465-9921-12-9.
8
Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease.慢性阻塞性肺疾病中慢性支气管炎的遗传易感性。
Respir Res. 2014 Sep 21;15(1):113. doi: 10.1186/s12931-014-0113-2.
9
Clinical and Radiologic Disease in Smokers With Normal Spirometry.肺功能正常的吸烟者的临床和放射学疾病
JAMA Intern Med. 2015 Sep;175(9):1539-49. doi: 10.1001/jamainternmed.2015.2735.
10
Genetic Advances in Chronic Obstructive Pulmonary Disease. Insights from COPDGene.慢性阻塞性肺疾病的遗传学进展。来自 COPDGene 的见解。
Am J Respir Crit Care Med. 2019 Sep 15;200(6):677-690. doi: 10.1164/rccm.201808-1455SO.
引用本文的文献
1
Prediction of Abnormal Functional Performance in Chronic Obstructive Pulmonary Disease Using Respiratory Models: A Pilot Study.使用呼吸模型预测慢性阻塞性肺疾病患者的异常功能表现：一项初步研究。
Int J Chron Obstruct Pulmon Dis. 2025 Aug 22;20:2945-2965. doi: 10.2147/COPD.S524591. eCollection 2025.
2
Hypoxic Status in COPD and ARDS Patients: Impact on Lipid Signature.慢性阻塞性肺疾病（COPD）和急性呼吸窘迫综合征（ARDS）患者的缺氧状态：对脂质特征的影响。
Int J Mol Sci. 2025 Jul 3;26(13):6405. doi: 10.3390/ijms26136405.
3
Alpha1-Antitrypsin in Lung Diseases: A Cross-Sectional Observational Study.α1抗胰蛋白酶在肺部疾病中的研究：一项横断面观察性研究。
Int J Mol Sci. 2025 Jun 4;26(11):5400. doi: 10.3390/ijms26115400.
4
Gender- and Age-Associated Variations in the Prevalence of Atelectasis, Effusion, and Nodules on Chest Radiographs: A Large-Scale Analysis Using the NIH ChestX-Ray8.胸部X光片上肺不张、胸腔积液和结节患病率的性别及年龄相关差异：使用美国国立卫生研究院（NIH）ChestX-Ray8的大规模分析
Diagnostics (Basel). 2025 May 26;15(11):1330. doi: 10.3390/diagnostics15111330.
5
Impact of intensive health education on influenza vaccination and acute exacerbations in outpatients with chronic obstructive pulmonary disease: a real-world study.强化健康教育对慢性阻塞性肺疾病门诊患者流感疫苗接种及急性加重的影响：一项真实世界研究
J Glob Health. 2025 Mar 7;15:04047. doi: 10.7189/jogh.15.04047.
6
Pulmonary Immunocompromise in Human Immunodeficiency Virus Disease.人类免疫缺陷病毒病中的肺部免疫功能低下
Clin Chest Med. 2025 Mar;46(1):185-201. doi: 10.1016/j.ccm.2024.10.014. Epub 2024 Nov 28.
7
Proteomic Analysis of Plasma Exosomes Enables the Identification of Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease.血浆外泌体的蛋白质组学分析有助于在慢性阻塞性肺疾病患者中识别肺癌。
Thorac Cancer. 2025 Jan;16(1):e15517. doi: 10.1111/1759-7714.15517.
8
Identifying biomarkers of endoplasmic reticulum stress and analyzing immune cell infiltration in chronic obstructive pulmonary disease using machine learning.利用机器学习识别内质网应激生物标志物并分析慢性阻塞性肺疾病中的免疫细胞浸润。
Front Med (Lausanne). 2024 Nov 22;11:1462868. doi: 10.3389/fmed.2024.1462868. eCollection 2024.
9
What every clinician should know about inflammation in COPD.每位临床医生都应了解的慢性阻塞性肺疾病中的炎症
ERJ Open Res. 2024 Sep 23;10(5). doi: 10.1183/23120541.00177-2024. eCollection 2024 Sep.
10
Sex and disease regulate major histocompatibility complex class I expression in human lung epithelial cells.性别和疾病调节人肺上皮细胞主要组织相容性复合体 I 类的表达。
Physiol Rep. 2024 Sep;12(17):e70025. doi: 10.14814/phy2.70025.
本文引用的文献
1
Pulmonary vascular pruning in smokers with bronchiectasis.支气管扩张症吸烟者的肺血管修剪
ERJ Open Res. 2018 Nov 23;4(4). doi: 10.1183/23120541.00044-2018. eCollection 2018 Oct.
2
Asthma Is a Risk Factor for Respiratory Exacerbations Without Increased Rate of Lung Function Decline: Five-Year Follow-up in Adult Smokers From the COPDGene Study.哮喘是导致成年吸烟者 COPDGene 研究中呼吸恶化而肺功能下降率无增加的一个风险因素：为期五年的随访。
Chest. 2018 Feb;153(2):368-377. doi: 10.1016/j.chest.2017.11.038. Epub 2017 Dec 15.
3
Chest computed tomography-derived low fat-free mass index and mortality in COPD.胸部 CT 衍生的低去脂体质量指数与 COPD 患者的死亡率。
Eur Respir J. 2017 Dec 14;50(6). doi: 10.1183/13993003.01134-2017. Print 2017 Dec.
4
Examining the Effects of Age on Health Outcomes of Chronic Obstructive Pulmonary Disease: Results From the Genetic Epidemiology of Chronic Obstructive Pulmonary Disease Study and Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate Endpoints Cohorts.探讨年龄对慢性阻塞性肺疾病健康结局的影响：来自慢性阻塞性肺疾病遗传流行病学研究和评估慢性阻塞性肺疾病纵向以确定预测替代终点队列的结果。
J Am Med Dir Assoc. 2017 Dec 1;18(12):1063-1068. doi: 10.1016/j.jamda.2017.09.028.
5
Alpha-1 Antitrypsin PiMZ Genotype Is Associated with Chronic Obstructive Pulmonary Disease in Two Racial Groups.α-1 抗胰蛋白酶 PiMZ 基因型与两个种族群体的慢性阻塞性肺疾病有关。
Ann Am Thorac Soc. 2017 Aug;14(8):1280-1287. doi: 10.1513/AnnalsATS.201611-838OC.
6
Pulmonary Predictors of Incident Diabetes in Smokers.吸烟者新发糖尿病的肺部预测因素
Chronic Obstr Pulm Dis. 2016;3(4):739-747. doi: 10.15326/jcopdf.3.4.2016.0137.
7
Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.SPIROMICS和COPDGene队列中预测病情加重的生物标志物
Am J Respir Crit Care Med. 2017 Feb 15;195(4):473-481. doi: 10.1164/rccm.201607-1330OC.
8
Obesity Is Associated With Increased Morbidity in Moderate to Severe COPD.肥胖与中重度慢性阻塞性肺疾病（COPD）发病率增加相关。
Chest. 2017 Jan;151(1):68-77. doi: 10.1016/j.chest.2016.08.1432. Epub 2016 Aug 25.
9
Acute Exacerbations and Lung Function Loss in Smokers with and without Chronic Obstructive Pulmonary Disease.患有和未患有慢性阻塞性肺疾病的吸烟者的急性加重期及肺功能丧失
Am J Respir Crit Care Med. 2017 Feb 1;195(3):324-330. doi: 10.1164/rccm.201605-1014OC.
10
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema.基于支气管扩张剂反应和肺气肿程度定义的哮喘-慢性阻塞性肺疾病重叠综合征分析
Ann Am Thorac Soc. 2016 Sep;13(9):1483-9. doi: 10.1513/AnnalsATS.201511-761OC.
Zotero 插件