Attia Engi F, Maleche-Obimbo Elizabeth, Ellington Laura E, North Crystal M
Division of Pulmonary, Critical Care and Sleep Medicine, Departments of Medicine and Global Health, University of Washington School of Medicine, Seattle, WA, USA.
Department of Pediatrics and Child Health, University of Nairobi, Nairobi, Kenya.
Clin Chest Med. 2025 Mar;46(1):185-201. doi: 10.1016/j.ccm.2024.10.014. Epub 2024 Nov 28.
The spectrum of pulmonary disease in people with human immunodeficiency virus (PWH) across the lifespan has shifted from acute, infectious, and acquired immunodeficiency syndrome (AIDS)-defining illnesses to a greater burden of chronic, non-communicable processes. Here, the authors review the epidemiology and risk factors of pulmonary disease in PWH across the lifespan during the contemporary antiretroviral therapy era. The authors focus on recommendations for clinical care of pulmonary disease relevant to PWH, including emerging data from recent and ongoing clinical trials.
在整个生命周期中，感染人类免疫缺陷病毒（PWH）者的肺部疾病谱已从急性、感染性及获得性免疫缺陷综合征（AIDS）定义的疾病，转变为慢性、非传染性疾病过程带来的更大负担。在此，作者回顾了当代抗逆转录病毒治疗时代PWH在整个生命周期中肺部疾病的流行病学和危险因素。作者重点关注与PWH相关的肺部疾病临床护理建议，包括近期及正在进行的临床试验的新数据。
