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Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise trophoblast-endometrium cross-talk.大麻衍生的大麻素抑制子宫内膜基质细胞的蜕膜化，损害滋养层-子宫内膜的相互作用。
Reprod Toxicol. 2019 Aug;87:100-107. doi: 10.1016/j.reprotox.2019.05.064. Epub 2019 May 30.
2
Preimplantation factor modulates trophoblastic invasion throughout the decidualization of human endometrial stromal cells.着床前因子调节人子宫内膜基质细胞的整个蜕膜化过程中的滋养细胞浸润。
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Reproduction. 2016 Oct;152(4):351-61. doi: 10.1530/REP-16-0364.
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Effects of a combination of cannabidiol and delta-9-tetrahydrocannabinol on key biological functions of HTR-8/SVneo extravillous trophoblast cells.大麻二酚与Δ9-四氢大麻酚联合作用对 HTR-8/SVneo 绒毛外滋养层细胞关键生物学功能的影响。
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Sex steroids regulate epithelial-stromal cell cross talk and trophoblast attachment invasion in a three-dimensional human endometrial culture system.性激素调节三维人子宫内膜培养系统中上皮-间质细胞的串扰和滋养细胞附着侵袭。
Tissue Eng Part C Methods. 2013 Sep;19(9):676-87. doi: 10.1089/ten.TEC.2012.0616. Epub 2013 Feb 19.
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Stromal cell senescence contributes to impaired endometrial decidualization and defective interaction with trophoblast cells.基质细胞衰老导致子宫内膜蜕膜化受损和与滋养层细胞的相互作用缺陷。
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Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation.人滋养层细胞和子宫内膜基质中IGFBP - 4蛋白酶及其生理抑制剂的鉴定与调控：人类着床期间胎盘床中IGF - II生物利用度旁分泌调控的证据
J Clin Endocrinol Metab. 2002 May;87(5):2359-66. doi: 10.1210/jcem.87.5.8448.
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Mol Cell Endocrinol. 2005 Jan 14;229(1-2):65-74. doi: 10.1016/j.mce.2004.09.007.
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Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling.大麻二酚（CBD）而非四氢大麻酚（THC）通过破坏雌激素信号转导来失调体外人子宫内膜基质细胞的蜕膜化。
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Arch Toxicol. 2019 Dec;93(12):3601-3615. doi: 10.1007/s00204-019-02601-8. Epub 2019 Oct 23.

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Int J Mol Sci. 2024 Jul 23;25(15):8031. doi: 10.3390/ijms25158031.
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Emerging Roles of Endocannabinoids as Key Lipid Mediators for a Successful Pregnancy.内源性大麻素作为成功妊娠的关键脂质介质的新兴作用。
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Metabolic Consequences of Gestational Cannabinoid Exposure.妊娠期暴露于大麻素的代谢后果。
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Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts.大麻二酚干扰胎盘滋养层细胞的凋亡、自噬和侵袭过程。
Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
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Cannabis and Cannabinoids in Reproduction and Fertility: Where We Stand.大麻及大麻素在生殖与生育中的现状
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(Endo)Cannabinoids and Gynaecological Cancers.内源性大麻素与妇科癌症
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A Balanced Approach for Cannabidiol Use in Chronic Pain.大麻二酚用于慢性疼痛的平衡方法。
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本文引用的文献

1
Hepatic Enzymes Relevant to the Disposition of (-)-∆-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC.与 (-)-∆-四氢大麻酚 (THC) 及其精神活性代谢物 11-OH-THC 处置相关的肝酶。
Drug Metab Dispos. 2019 Mar;47(3):249-256. doi: 10.1124/dmd.118.085548. Epub 2018 Dec 19.
2
Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta.大麻的使用会对早期妊娠人子宫内膜和胎盘中的大麻素受体表达产生差异影响。
Placenta. 2018 Jun;66:36-39. doi: 10.1016/j.placenta.2018.05.002. Epub 2018 May 9.
3
Marijuana Use, Recent Marijuana Initiation, and Progression to Marijuana Use Disorder Among Young Male and Female Adolescents Aged 12-14 Living in US Households.居住在美国普通家庭的12至14岁青少年中，男性和女性使用大麻、近期开始使用大麻以及发展为大麻使用障碍的情况。
Subst Abuse. 2017 Jun 6;11:1178221817711159. doi: 10.1177/1178221817711159. eCollection 2017.
4
Suppression of STAT3 Signaling by Δ9-Tetrahydrocannabinol (THC) Induces Trophoblast Dysfunction.Δ9-四氢大麻酚（THC）对信号转导和转录激活因子3（STAT3）信号通路的抑制作用会导致滋养层细胞功能障碍。
Cell Physiol Biochem. 2017;42(2):537-550. doi: 10.1159/000477603. Epub 2017 Jun 5.
5
miR-181b-5p Modulates Cell Migratory Proteins, Tissue Inhibitor of Metalloproteinase 3, and Annexin A2 During In Vitro Decidualization in a Human Endometrial Stromal Cell Line.miR-181b-5p 在体外人子宫内膜基质细胞蜕膜化过程中调节细胞迁移蛋白、金属蛋白酶组织抑制剂 3 和膜联蛋白 A2。
Reprod Sci. 2017 Sep;24(9):1264-1274. doi: 10.1177/1933719116682877. Epub 2016 Dec 21.
6
Determination of ∆-9-Tetrahydrocannabinol (THC), 11-hydroxy-THC, 11-nor-9-carboxy-THC and Cannabidiol in Human Plasma using Gas Chromatography-Tandem Mass Spectrometry.采用气相色谱-串联质谱法测定人血浆中的Δ-9-四氢大麻酚（THC）、11-羟基-THC、11-去甲-9-羧基-THC和大麻二酚
J Anal Toxicol. 2017 May 1;41(4):277-288. doi: 10.1093/jat/bkw136.
7
The Risks of Marijuana Use During Pregnancy.孕期使用大麻的风险。
JAMA. 2017 Jan 10;317(2):129-130. doi: 10.1001/jama.2016.18612.
8
Trends in Marijuana Use Among Pregnant and Nonpregnant Reproductive-Aged Women, 2002-2014.2002 - 2014年怀孕及未怀孕育龄妇女大麻使用趋势
JAMA. 2017 Jan 10;317(2):207-209. doi: 10.1001/jama.2016.17383.
9
Prenatal exposure to cannabis and maternal and child health outcomes: a systematic review and meta-analysis.产前接触大麻与母婴健康结局：一项系统评价和荟萃分析。
BMJ Open. 2016 Apr 5;6(4):e009986. doi: 10.1136/bmjopen-2015-009986.
10
Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth.内源性大麻素信号持续存在会损害蜕膜功能并促进炎症诱导的早产。
J Biol Chem. 2016 Apr 8;291(15):8231-40. doi: 10.1074/jbc.M115.707836. Epub 2016 Feb 21.

大麻衍生的大麻素抑制子宫内膜基质细胞的蜕膜化，损害滋养层-子宫内膜的相互作用。

Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise trophoblast-endometrium cross-talk.

机构信息

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.

出版信息

Reprod Toxicol. 2019 Aug;87:100-107. doi: 10.1016/j.reprotox.2019.05.064. Epub 2019 May 30.

DOI:10.1016/j.reprotox.2019.05.064
PMID:31154070
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6613995/
Abstract

Marijuana (cannabis) use by pregnant women in the United States is increasing and there is a dire need to understand the beneficial or harmful effects of cannabis during pregnancy. Uterine endometrial stromal cells are fibroblast-like cells that differentiate into secretory cells, a process called decidualization, to create a microenvironment conducive for placenta formation and early embryonic growth. In this study, using model human cell lines, we for the first time demonstrate that Δ-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) inhibit endometrial stromal cell decidualization and have adverse effects on trophoblast-endometrium cross-talk.

摘要

美国孕妇的大麻（大麻）使用率正在上升，因此迫切需要了解怀孕期间大麻的有益或有害影响。子宫子宫内膜基质细胞是成纤维样细胞，可分化为分泌细胞，这一过程称为蜕膜化，以创造有利于胎盘形成和早期胚胎生长的微环境。在这项研究中，我们首次使用模型人细胞系证明，Δ-四氢大麻酚（THC）、大麻二酚（CBD）和大麻酚（CBN）抑制子宫内膜基质细胞的蜕膜化，并对滋养层-子宫内膜的相互作用产生不利影响。