大麻衍生的大麻素抑制子宫内膜基质细胞的蜕膜化，损害滋养层-子宫内膜的相互作用。
Marijuana-derived cannabinoids inhibit uterine endometrial stromal cell decidualization and compromise trophoblast-endometrium cross-talk.
机构信息
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, WA 98195, USA.
出版信息
Reprod Toxicol. 2019 Aug;87:100-107. doi: 10.1016/j.reprotox.2019.05.064. Epub 2019 May 30.
Abstract
Marijuana (cannabis) use by pregnant women in the United States is increasing and there is a dire need to understand the beneficial or harmful effects of cannabis during pregnancy. Uterine endometrial stromal cells are fibroblast-like cells that differentiate into secretory cells, a process called decidualization, to create a microenvironment conducive for placenta formation and early embryonic growth. In this study, using model human cell lines, we for the first time demonstrate that Δ-tetrahydrocannabinol (THC), cannabidiol (CBD) and cannabinol (CBN) inhibit endometrial stromal cell decidualization and have adverse effects on trophoblast-endometrium cross-talk.
摘要
美国孕妇的大麻（大麻）使用率正在上升，因此迫切需要了解怀孕期间大麻的有益或有害影响。子宫子宫内膜基质细胞是成纤维样细胞，可分化为分泌细胞，这一过程称为蜕膜化，以创造有利于胎盘形成和早期胚胎生长的微环境。在这项研究中，我们首次使用模型人细胞系证明，Δ-四氢大麻酚（THC）、大麻二酚（CBD）和大麻酚（CBN）抑制子宫内膜基质细胞的蜕膜化，并对滋养层-子宫内膜的相互作用产生不利影响。
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