Astekar Madhusudan, Choubey Rajkumar R, Manjunatha Bhari Sharanesha, Gupta Santosh
Department of Oral and Maxillofacial Pathology, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.
Department of Oral Biology, Basic Dental Sciences, Faculty of Dentistry, Taif, Saudi Arabia.
BMJ Case Rep. 2019 May 31;12(5):e227456. doi: 10.1136/bcr-2018-227456.
Malignancy of melanocytes, a pigment-producing cell, is referred as malignant melanoma (MM) which occur basically on skin and oral mucous membrane, but as well found in ears, eyes, gastrointestinal tract and genital mucosa. Oral melanomas has propensity to metastasise and invade more voluntarily than other malignant counterparts. Here we present a case of 52-year-old male patient with a chief symptom of blackening of gums in the upper front tooth region. In dental history, the patient revealed history of faulty artificial prosthesis fixed in the same region since 6 months. On the basis of a through clinical assessment, a provisional opinion of oral malignant melanoma, was prepared. On histopathological and immunohistochemical analysis with S-100 and homatropine methylbromide 45 the diagnosis of MM was confirmed.
黑色素细胞（一种产生色素的细胞）的恶性肿瘤被称为恶性黑色素瘤（MM），其主要发生在皮肤和口腔黏膜，但也见于耳朵、眼睛、胃肠道和生殖黏膜。口腔黑色素瘤比其他恶性肿瘤更易发生转移和侵袭。在此，我们报告一例52岁男性患者，主要症状为上前牙区牙龈变黑。在牙科病史中，患者透露自6个月前起在同一区域佩戴了不合适的固定假牙。基于全面的临床评估，初步诊断为口腔恶性黑色素瘤。经S-100和甲基溴化后马托品的组织病理学和免疫组织化学分析，确诊为MM。
