银屑病和银屑病关节炎中的心血管疾病

Cardiovascular Diseases in Psoriasis and Psoriatic Arthritis.

作者信息

Eder Lihi, Dey Amit, Joshi Aditya A, Boehncke Wolf-Henning, Mehta Nehal N, Szentpetery Agnes

机构信息

From the Women's College Research Institute, Women's College Hospital, University of Toronto, Toronto, Ontario, Canada; Laboratory of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, Maryland, USA; Division of Dermatology and Venereology, Geneva University Hospitals, and Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland; Department of Rheumatology, Uppsala University Hospital, Uppsala, Sweden.

L. Eder, MD, PhD, Women's College Research Institute, Women's College Hospital, University of Toronto; A. Dey, MD, Laboratory of Inflammation and Cardiometabolic Diseases, NHLBI, NIH; A.A. Joshi, MD, Laboratory of Inflammation and Cardiometabolic Diseases, NHLBI, NIH; W.H. Boehncke, MD, Professor and Chair, Division of Dermatology and Venereology, Geneva University Hospitals, and Department of Pathology and Immunology, University of Geneva; N.N. Mehta, MD, MSCE, Laboratory of Inflammation and Cardiometabolic Diseases, NHLBI, NIH; A. Szentpetery, MD, PhD, Department of Rheumatology, Uppsala University Hospital.

出版信息

J Rheumatol Suppl. 2019 Jun;95:20-27. doi: 10.3899/jrheum.190114.

DOI:10.3899/jrheum.190114

PMID:31154400

Abstract

Patients with psoriatic disease have an increased risk of developing cardiovascular (CV) events. Recent advances in imaging and biomarker research provide insights into the underlying mechanisms that link these conditions. Here, we summarize recent work in this field that was presented at the July 2018 Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) annual meeting in Toronto, Ontario, Canada. The presentations highlighted recent data about the association between psoriasis and vascular inflammation, the use of coronary angiogram to investigate CV outcomes, new approaches for CV risk stratification, and the shared pathomechanisms of psoriasis and atherosclerosis.

摘要

银屑病患者发生心血管（CV）事件的风险增加。成像和生物标志物研究的最新进展为连接这些病症的潜在机制提供了见解。在此，我们总结了该领域最近在2018年7月于加拿大多伦多安大略省举行的银屑病和银屑病关节炎研究与评估小组（GRAPPA）年会上发表的研究成果。这些报告强调了关于银屑病与血管炎症之间关联的最新数据、使用冠状动脉造影来研究CV结局、CV风险分层的新方法，以及银屑病和动脉粥样硬化的共同病理机制。