School of Sciences and Humanities, Nazarbayev University, Nur-Sultan, Kazakhstan.
Faculty of Education and Humanities, Suleyman Demirel University, Almaty, Kazakhstan.
Front Immunol. 2020 Oct 1;11:571319. doi: 10.3389/fimmu.2020.571319. eCollection 2020.
Psoriasis is a chronic inflammatory condition that predominantly affects the skin and is associated with extracutaneous disorders, such as inflammatory bowel disease and arthritis. Changes in gut immunology and microbiota are important drivers of proinflammatory disorders and could play a role in the pathogenesis of psoriasis. Therefore, we explored whether psoriasis in a Central Asian cohort is associated with alterations in select immunological markers and/or microbiota of the gut.
We undertook a case-control study of stool samples collected from outpatients, aged 30-45 years, of a dermatology clinic in Kazakhstan presenting with plaque, guttate, or palmoplantar psoriasis ( = 20), and age-sex matched subjects without psoriasis ( = 20). Stool supernatant was subjected to multiplex ELISA to assess the concentration of 47 cytokines and immunoglobulins and to 16S rRNA gene sequencing to characterize microbial diversity in both psoriasis participants and controls.
The psoriasis group tended to have higher concentrations of most analytes in stool (29/47 = 61.7%) and gut IL-1α was significantly elevated (4.19-fold, = 0.007) compared to controls. Levels of gut IL-1α in the psoriasis participants remained significantly unaltered up to 3 months after the first sampling ( = 0.430). Psoriasis was associated with alterations in gut , including elevated and decreased and abundance, but no association was observed between gut microbial diversity or ratios and disease status.
Psoriasis may be associated with gut inflammation and dysbiosis. Studies are warranted to explore the use of gut microbiome-focused therapies in the management of psoriasis in this under-studied population.
银屑病是一种慢性炎症性疾病，主要影响皮肤，并与肠道外疾病有关，如炎症性肠病和关节炎。肠道免疫和微生物群的变化是促炎疾病的重要驱动因素，并且可能在银屑病的发病机制中发挥作用。因此，我们探讨了中亚队列中的银屑病是否与肠道中特定免疫标志物和/或微生物群的改变有关。
我们对来自哈萨克斯坦一家皮肤科诊所的 30-45 岁门诊患者的粪便样本进行了病例对照研究，这些患者患有斑块状、点滴状或掌跖状银屑病（ = 20 例），并与年龄和性别匹配的无银屑病患者（ = 20 例）进行了对照。对粪便上清液进行了多重 ELISA 检测，以评估 47 种细胞因子和免疫球蛋白的浓度，并进行了 16S rRNA 基因测序，以评估银屑病患者和对照者肠道微生物多样性。
银屑病组的粪便中大多数分析物的浓度较高（29/47 = 61.7%），并且肠道白介素-1α显著升高（4.19 倍， = 0.007），与对照组相比。在首次采样后 3 个月内，银屑病患者的肠道白介素-1α水平仍保持显著不变（ = 0.430）。银屑病与肠道 有关，包括升高的 和降低的 和 丰度，但肠道微生物多样性或 比值与疾病状态之间没有关联。
银屑病可能与肠道炎症和菌群失调有关。有必要进行研究，以探讨在这一研究较少的人群中使用肠道微生物组为重点的治疗方法来治疗银屑病。
