Mouret J, Lemoine P, Minuit M P
Unité clinique de Psychiatrie biologique, Hôpital du Vinatier, Bron.
C R Acad Sci III. 1987;305(8):301-6.
Among patients referred for areactive depression who were polygraphically recorded after at least 2 weeks without any pharmacological treatment, some were found to present qualitative sleep symptoms similar to those already described in clinically diagnosed parkinsonian patients. A therapeutic trail with a dopamine agonist (Piribedil) was followed, in all of these patients, by a dramatic and rapid improvement of mood. As compared to areactive depressive patients whose sleep recordings were free of these qualitative abnormalities, some quantitative sleep criteria, mainly related to REM sleep, permit to diagnose this group of dopamine dependent depression (DDD). These data, together with the beneficial effect of Piribedil, favor a role of DA in the genesis of this type of depression. Some clinical signs now appear as sufficient to diagnose these DDD. The interest of this study is that all the patients (now 48), among whom no clinical parkinsonian symptoms were found, diagnosed according to the reported polygraphic criteria were cured following this treatment.
在因反应性抑郁症转诊且至少停药2周后进行多导睡眠图记录的患者中，发现部分患者存在与临床诊断的帕金森病患者已描述的类似的定性睡眠症状。对所有这些患者采用多巴胺激动剂（吡贝地尔）进行治疗试验后，患者情绪显著且迅速改善。与睡眠记录无这些定性异常的反应性抑郁症患者相比，一些主要与快速眼动睡眠相关的定量睡眠标准有助于诊断这组多巴胺依赖性抑郁症（DDD）。这些数据，连同吡贝地尔的有益作用，支持多巴胺在这类抑郁症发病机制中的作用。现在一些临床体征似乎足以诊断这些DDD。本研究的意义在于，根据所报告的多导睡眠图标准诊断出的所有患者（目前为48例），在未发现临床帕金森病症状的情况下，经此治疗均已治愈。
