Guillaume R, Charles G, Mesters P, Schittecatte M, Wilmotte J
Hôpital Vicent Van Gogh, Marchienne-au-Pont, Belgique.
Acta Psychiatr Belg. 1988 Mar-Apr;88(2):153-61.
Piribedil, a dopaminergic agonist, was administered intravenously (0.5 mg over 10 minutes) to two unipolar endogenous depressed. The two patients, a 38-year-old man and a 60-year-old woman, were matched for age and sex with two volunteers without any mental illness. Effects of piribedil on plasma levels of growth hormone and on blood pressure were studied. The two volunteers evaluated their "feelings" of anxiety and of physical comfort using visual analogue scales. The experimentation was repeated in a double blind fashion with a placebo. Piribedil induced an elevation of GH in the normal man but not in the depressed man. In contrast, no increase was noted in women. No elevation of GH was observed after placebo. Importance of factors such as depression, sexual steroid environment and influence of stress are discussed.
吡贝地尔，一种多巴胺能激动剂，以静脉注射的方式（10分钟内注射0.5毫克）给予两名单相内源性抑郁症患者。这两名患者，一名38岁男性和一名60岁女性，在年龄和性别上与两名无精神疾病的志愿者相匹配。研究了吡贝地尔对生长激素血浆水平和血压的影响。两名志愿者使用视觉模拟量表评估他们的焦虑“感受”和身体舒适度。实验以双盲方式使用安慰剂重复进行。吡贝地尔使正常男性的生长激素升高，但抑郁症男性未出现这种情况。相比之下，女性未观察到升高。安慰剂给药后未观察到生长激素升高。讨论了抑郁症、性类固醇环境和压力影响等因素的重要性。
