Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, Huazhong University of Science and Technology, Wuhan, China.
Int J Gynaecol Obstet. 2019 Sep;146(3):308-314. doi: 10.1002/ijgo.12878. Epub 2019 Jun 25.
To evaluate the association between sleep patterns (sleep duration or timing) in late pregnancy and adverse birth outcomes (preterm delivery or small for gestational age, SGA).
An analysis of data from a prospective cohort study of pregnant women in Wuhan city, Hubei Province, China, between 2012 and 2014. Preterm delivery was defined as delivery before 37 gestational weeks. SGA was defined as neonatal birthweight below the 10th percentile of the predicted birthweight distribution.
In total, 11 192 women were included in the analysis. After adjustment for potential confounders, 9.1-10 hours of nocturnal sleep was associated with a lower likelihood of SGA (odds ratio [OR], 0.81; 95% confidence interval [CI], 0.66-0.99) as compared with 7.1-9 hours. As compared with intermediate mid-sleep time (between 02:46 and 04:00), early mid-sleep time (at or earlier than 02:45) was associated with a higher likelihood of preterm delivery (OR, 1.64; 95% CI, 1.28-2.10).
Among a large cohort of pregnant Chinese women, 9.1-10 hours of nocturnal sleep was associated with a lower risk of SGA, whereas early mid-sleep time was associated with a higher risk of preterm delivery.
评估妊娠晚期睡眠模式（睡眠时间或时间）与不良出生结局（早产或小于胎龄儿，SGA）之间的关联。
对 2012 年至 2014 年期间湖北省武汉市进行的一项前瞻性孕妇队列研究的数据进行分析。早产定义为妊娠 37 周前分娩。SGA 定义为新生儿出生体重低于预测出生体重分布的第 10 个百分位数。
共纳入 11192 名女性进行分析。在调整潜在混杂因素后，与 7.1-9 小时相比，9.1-10 小时的夜间睡眠时间与 SGA 的可能性降低相关（比值比[OR]，0.81；95%置信区间[CI]，0.66-0.99）。与中间午睡时间（02:46 至 04:00 之间）相比，早期午睡时间（02:45 或更早）与早产的可能性增加相关（OR，1.64；95%CI，1.28-2.10）。
在一项大型中国孕妇队列中，9.1-10 小时的夜间睡眠时间与 SGA 风险降低相关，而早期午睡时间与早产风险增加相关。
