Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, PR China.
Department of Preventive Medicine, Henan University of Chinese Medicine, 156 East Jinshui, Zhengzhou, Henan, 450046, PR China.
BMC Public Health. 2021 May 7;21(1):879. doi: 10.1186/s12889-021-10833-6.
The study aimed to investigate the independent and combined effects of midpoint of sleep and night sleep duration on type 2 diabetes mellitus (T2DM) in areas with limited resources.
A total of 37,276 participants (14,456 men and 22,820 women) were derived from the Henan Rural Cohort Study. Sleep information was assessed based on the Pittsburgh Sleep Quality Index. Logistic regression models and restricted cubic splines were used to estimate the relationship of the midpoint of sleep and night sleep duration with T2DM.
Of the 37,276 included participants, 3580 subjects suffered from T2DM. The mean midpoint of sleep among the Early, Intermediate and Late groups were 1:05 AM ±23 min, 1:56 AM ±14 min, and 2:57 AM ±34 min, respectively. Compared to the Intermediate group, adjusted odds ratios (ORs) and 95% confidence interval (CI) of T2DM were 1.13 (1.04-1.22) and 1.14 (1.03-1.26) in the Early group and the Late group. Adjusted OR (95% CI) for T2DM compared with the reference (7- h) was 1.28 (1.08-1.51) for longer (≥ 10 h) night sleep duration. The combination of late midpoint of sleep and night sleep duration (≥ 9 h) increased 38% (95% CI 10-74%) prevalence of T2DM. These associations were more obvious in women than men.
Late and early midpoint of sleep and long night sleep duration were all associated with higher prevalence of T2DM. Meanwhile, midpoint of sleep and night sleep duration might have combined effects on the prevalence of T2DM, which provided potential health implications for T2DM prevention, especially in rural women.
The Henan Rural Cohort Study has been registered at Chinese Clinical Trial Register (Registration number: ChiCTR-OOC-15006699 ). Date of registration: 2015-07-06.
本研究旨在探讨资源有限地区睡眠中点和夜间睡眠时间对 2 型糖尿病（T2DM）的独立和联合影响。
本研究共纳入 37276 名参与者（男 14456 人，女 22820 人），均来自河南农村队列研究。基于匹兹堡睡眠质量指数评估睡眠信息。采用 logistic 回归模型和限制立方样条分析睡眠中点和夜间睡眠时间与 T2DM 的关系。
在纳入的 37276 名参与者中，有 3580 名患有 T2DM。早睡组、中睡组和晚睡组的睡眠中点均值分别为 1:05 AM ±23 min、1:56 AM ±14 min 和 2:57 AM ±34 min。与中睡组相比，早睡组和晚睡组 T2DM 的调整优势比（OR）及其 95%置信区间（CI）分别为 1.13（1.04-1.22）和 1.14（1.03-1.26）。与参考组（7 h）相比，夜间睡眠时间较长（≥10 h）的 T2DM 调整 OR（95%CI）为 1.28（1.08-1.51）。睡眠中点较晚且夜间睡眠时间较长（≥9 h）会使 T2DM 的患病率增加 38%（95%CI 10-74%）。这些关联在女性中比男性中更为明显。
较晚和较早的睡眠中点以及较长的夜间睡眠时间均与 T2DM 的高患病率相关。同时，睡眠中点和夜间睡眠时间可能对 T2DM 的患病率具有联合效应，这为 T2DM 的预防提供了潜在的健康意义，尤其是对农村女性。
河南农村队列研究已在中国临床试验注册中心注册（注册号：ChiCTR-OOC-15006699）。注册日期：2015-07-06。
