寄生虫感染患者体内的微管蛋白抗体。
Antibodies to tubulin in patients with parasitic infections.
作者信息
Howard M K, Gull K, Miles M A
机构信息
Wolfson Unit/Department of Medical Protozoology, London School of Hygiene and Tropical Medicine, UK.
出版信息
Clin Exp Immunol. 1987 Apr;68(1):78-85.
Abstract
Sera from a total of 268 patients with protozoan, helminth, bacterial (leprosy and tuberculosis) infections or appropriate controls, were assayed for anti-tubulin antibodies in an indirect enzyme-linked immunosorbent assay (ELISA), using purified tubulin as antigen. Levels of serum anti-tubulin antibody were significantly elevated in 67% of patients with visceral leishmaniasis, in 60% of patients with cutaneous leishmaniasis, in 89% of patients with onchocerciasis, in 100% of patients with schistosomiasis, and in 94% of patients with leprosy. Little or no increase in anti-tubulin antibody levels was seen in sera from patients with malaria (Plasmodium vivax) or tuberculosis.
摘要
共收集了268例原生动物、蠕虫、细菌（麻风病和结核病）感染患者或相应对照的血清，以纯化微管蛋白为抗原，采用间接酶联免疫吸附测定法（ELISA）检测抗微管蛋白抗体。内脏利什曼病患者中67%、皮肤利什曼病患者中60%、盘尾丝虫病患者中89%、血吸虫病患者中100%以及麻风病患者中94%的血清抗微管蛋白抗体水平显著升高。疟疾（间日疟原虫）或结核病患者血清中抗微管蛋白抗体水平几乎没有升高或未见升高。
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