Moraes Neto Roberval Nascimento, Setúbal Ruth Flávia Barros, Higino Taciana Mirely Maciel, Brelaz-de-Castro Maria Carolina Accioly, da Silva Luís Cláudio Nascimento, Aliança Amanda Silva Dos Santos
Programa de Pós-Graduação da Universidade Ceuma, São Luís, Brazil.
Departamento de Investigação Científica, Fundação Altino Ventura, Recife, Brazil.
Front Pharmacol. 2019 May 8;10:477. doi: 10.3389/fphar.2019.00477. eCollection 2019.
Leishmaniasis and Chagas disease cause great impact on social and economic aspects of people living in developing countries. The treatments for these diseases are based on the same regimen for over 40 years, thus, there is an urgent need for the development of new drugs. In this scenario, Asteraceae plants (a family widely used in folk medicine worldwide) are emerging as an interesting source for new trypanocidal and leishmanicidal compounds. Herein, we provide a non-exhaustive review about the activity of plant-derived products from Asteraceae with inhibitory action toward spp. and . Special attention was given to those studies aiming the isolation (or identification) of the bioactive compounds. Ferulic acid, rosmarinic acid, and ursolic acid ( DC.) were efficient to treat experimental leishmaniasis; while deoxymikanolide () and (+)-15-hydroxy-labd-7-en-17-al ( Lam.) showed anti- action. It is also important to highlight that several plant-derived products (compounds, essential oils) from plants have shown high inhibitory potential against spp., such as artemisinin and its derivatives. In summary, these compounds may help the development of new effective agents against these neglected diseases.
利什曼病和恰加斯病对生活在发展中国家的人们的社会和经济方面造成了巨大影响。这些疾病的治疗方案已经沿用了40多年，因此，迫切需要开发新药。在这种情况下，菊科植物（一种在全球民间医学中广泛使用的植物科）正在成为新的抗锥虫和抗利什曼化合物的一个有趣来源。在此，我们对菊科植物衍生产品对锥虫属和利什曼原虫属的抑制活性进行了非详尽的综述。特别关注了那些旨在分离（或鉴定）生物活性化合物的研究。阿魏酸、迷迭香酸和熊果酸（DC.）对治疗实验性利什曼病有效；而脱氧米卡诺内酯（）和（+）-15-羟基-labd-7-烯-17-醛（Lam.）显示出抗锥虫作用。还需要强调的是，菊科植物的几种植物衍生产品（化合物、精油）对锥虫属显示出高抑制潜力，如青蒿素及其衍生物。总之，这些化合物可能有助于开发针对这些被忽视疾病的新的有效药物。
