Laboratory of Pharmacology, Neurobiology and Behavior, Semlalia Faculty of Sciences, Cadi Ayyad University, Marrakech, Morocco.
Laboratory of Génie Biologique, Sultan Moulay Slimane University, Faculty of Sciences and Techniques, Béni Mellal, Morocco.
J Ethnopharmacol. 2018 Nov 15;226:105-110. doi: 10.1016/j.jep.2018.08.017. Epub 2018 Aug 16.
Pregnant women prefer herbal medicines more than pharmaceutical drugs due to the cultural belief that herbs are more suffer during pregnancy for an accurate foetus development. Artemisia herba-alba (Asteraceae) is one of the most used plants in the Mediterranean region to treat various diseases including diabetes, hypertension, spasmodic dysphonia and some bacterial infection.
The present study aimed to investigate the effect of Artemisia herba-alba consumption during pregnancy on fertility, physical and behavior developments of mice offspring from birth-to-weaning days.
Female pregnant mice were divided into three groups and orally administrated with 80 and 150 mg/kg/day of the methanol extract of Artemisia h.a respectively, during the entire period of gestation. At birth, total fertility rate was counted. Body development; neuromotor reflex and behavior were also examined in mice offspring RESULTS: Artemisia h.a (Aha) exposure significantly decreased the fertility ratio in both Aha-treated groups and increased the weight and length of mice offspring in 80 mg/kg/day Aha-exposed group. Moreover, Aha administration prolonged the time of completing the reflex response of surface righting, negative geotaxis, cliff avoidance and jumping test of mice offspring in Aha-exposed groups.
The present study provides strong evidence that discourage the use of Artemisia h.a during gestation period.
由于文化信仰认为草药在怀孕期间对胎儿的发育更有益，因此孕妇比药物更倾向于使用草药。Artemisia herba-alba（菊科）是地中海地区最常被用于治疗各种疾病的植物之一，包括糖尿病、高血压、痉挛性发音困难和某些细菌感染。
本研究旨在探讨在妊娠期间食用Artemisia herba-alba 对小鼠后代从出生到断奶期间的生育能力、身体和行为发育的影响。
将雌性怀孕小鼠分为三组，分别灌胃 80 和 150mg/kg/天的 Artemisia h.a 甲醇提取物，持续整个妊娠期。在出生时，计算总生育率。还检查了小鼠后代的身体发育、神经运动反射和行为。
Artemisia h.a（Aha）暴露显著降低了两个 Aha 处理组的生育比例，并增加了 80mg/kg/天 Aha 暴露组小鼠后代的体重和长度。此外，Aha 给药延长了 Aha 暴露组小鼠完成表面翻正、负趋地、悬崖回避和跳跃测试的反射反应时间。
本研究提供了有力的证据，不鼓励在妊娠期间使用 Artemisia h.a。
