Tada T, Katsuyama T, Aoki T, Kobayashi S, Shigematsu H
Department of Neurosurgery, Shinshu University School of Medicine, Shinshu University Hospital, Matsumoto, Japan.
Clin Neuropathol. 1987 Jul-Aug;6(4):160-3.
A 56-year-old man had a right temporal lobe tumor with calcification, which was removed surgically and treated with irradiation. The histology of the tumor was mixed tumor of glioblastoma and fibrosarcoma, and in the sarcoma portion osteoid-chondral tissue was found. With stains for proteoglycan and enzyme digestion tests, hyaluronic acid and chondroitin sulfate were demonstrated in the cartilage matrix. The positive reactivity of the proteoglycans to high iron diamine staining in the first surgical specimens changed to negative in the second and autopsy specimens. It is likely that the osteoid-chondral tissue derived from metaplastic change in sarcoma cells and in the later stage pleomorphism appeared.
一名56岁男性患有右颞叶肿瘤伴钙化，该肿瘤经手术切除并接受放疗。肿瘤组织学检查为胶质母细胞瘤和纤维肉瘤的混合瘤，在肉瘤部分发现了类骨软骨组织。通过蛋白聚糖染色和酶消化试验，在软骨基质中证实了透明质酸和硫酸软骨素的存在。在首次手术标本中，蛋白聚糖对高铁二胺染色呈阳性反应，而在第二次手术标本和尸检标本中变为阴性。类骨软骨组织可能源自肉瘤细胞的化生改变，且在后期出现了多形性。
