Association of rs712 polymorphism in a let-7 microRNA-binding site of gene with colorectal cancer in a Mexican population.

OBJECTIVES

The rs712 polymorphism in a let-7 microRNA-binding site at gene has been associated with cancer. To examine its association with rs712 polymorphism, we analyzed Mexican individuals with colorectal cancer (CRC) and healthy subjects.

MATERIALS AND METHODS

Genotyping of the rs712 polymorphism was performed by polymerase chain reaction in 281 controls and 336 CRC patients.

RESULTS

The observed frequencies of rs712 polymorphism indicated an associated protective factor for CRC (=0.032). An association between genotype and the disease was evident in: colon localization (allele odds ratio (OR) 3.82, 95% confidence Intervals (CI) 2.77-5.28, =0.0001), node metastasis (genotype OR 2.49, 95% CI 1.45-4.28, =0.0009), poor differentiation (genotype GT, OR 2.35, 95% CI 1.35-4.1, =0.0033), and poor chemotherapy response (genotype GT, OR 2.6, 95% CI 1.7-4.24, =0.0001).

CONCLUSION

Comparison of the data from patients with control group showed that polymorphism of rs712 in gene was protective factor, which was associated with susceptibility for CRC. However, the genotypes and of rs712 polymorphism in could contribute significantly to colon localization, node metastasis, poor differentiation and poor chemotherapy response in CRC patients in this sample population.