Skeie B, Askanazi J, Rothkopf M M, Rosenbaum S H, Kvetan V, Ross E
Department of Anesthesiology, Columbia University College of Physicians and Surgeons, New York City, NY.
Crit Care Med. 1987 Oct;15(10):960-2. doi: 10.1097/00003246-198710000-00014.
Two cystic fibrosis (CF) patients with severe pulmonary disease and malnutrition were followed during a course of long-term home total parenteral nutrition (TPN), which included iv fat emulsion. They gained 7 and 12 kg in body weight, respectively, and their ability to participate in daily activities increased. Progressive exercise testing before and during TPN showed a marked increase in maximal work load: 100% and 30%, respectively. At any given work load, oxygen uptake was increased while the respiratory quotient remained lower after the course of TPN. We believe that the lower respiratory quotient and greater oxygen consumption during exercise were due to a reduction in anaerobic metabolism after TPN.
两名患有严重肺部疾病和营养不良的囊性纤维化（CF）患者在长期家庭全胃肠外营养（TPN）治疗过程中接受了随访，该治疗包括静脉输注脂肪乳剂。他们的体重分别增加了7千克和12千克，并且参与日常活动的能力有所提高。在TPN治疗前和治疗期间进行的渐进性运动测试显示，最大工作量显著增加：分别增加了100%和30%。在任何给定的工作量下，TPN治疗后氧摄取增加，而呼吸商保持较低水平。我们认为，运动期间较低的呼吸商和较高的氧消耗是由于TPN治疗后无氧代谢减少所致。
