Wang Lijiang, Zhang Jirong, Yu Xiaoqing, Wang Jiuzhong, Cheng Lifeng, Hu Shuzhen, Han Guangliang
Department of Neurosurgery, Shengli Oilfield Central Hospital of Binzhou Medical University, Dongying, Shandong, China.
Eur J Hosp Pharm. 2017 May;24(3):182-184. doi: 10.1136/ejhpharm-2016-000972. Epub 2016 Jun 24.
The ubiquitous is an important and troublesome pathogen of nosocomial infection. Multidrug-resistant meningitis is very difficult to treat, usually with high mortality. The disease is generally associated with craniotomy, but rarely with lumbar puncture. However, in our case, a 45-year-old male construction worker suffered multidrug-resistant meningitis associated with lumbar puncture. The patient responded poorly to the initial treatment with an intravenous infusion of tigecycline. However, later treatment with an intrathecal injection of tigecycline (concentration 1 mg/mL) at a dose of 10 mg every 12 hours proved to be highly efficacious. Thus, intrathecal injection of tigecycline should be seriously considered as a treatment for multidrug-resistant meningitis.
无处不在的[病原体名称未给出]是医院感染的一种重要且棘手的病原体。耐多药[病原体名称未给出]性脑膜炎很难治疗，通常死亡率很高。该疾病一般与开颅手术有关，但很少与腰椎穿刺有关。然而，在我们的病例中，一名45岁的男性建筑工人患上了与腰椎穿刺相关联的耐多药[病原体名称未给出]性脑膜炎。患者对初始静脉输注替加环素治疗反应不佳。然而，后来每12小时鞘内注射10毫克替加环素（浓度1毫克/毫升）的治疗被证明非常有效。因此，鞘内注射替加环素应被认真考虑作为耐多药[病原体名称未给出]性脑膜炎的一种治疗方法。
