多黏菌素 B 和替加环素成功治疗广泛耐药性脑室炎：一例报告。
Successful treatment of extensively drug-resistant ventriculitis with polymyxin B and tigecycline- a case report.
机构信息
Department of Neurosurgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038 China.
出版信息
Antimicrob Resist Infect Control. 2018 Feb 14;7:22. doi: 10.1186/s13756-018-0313-5. eCollection 2018.
BACKGROUND
nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier.
CASE PRESENTATION
A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of after the decompressive craniectomy for severe traumatic brain injury. The patient was successfully treated with intraventricular and intravenous polymyxin B together with intravenous tigecycline.
CONCLUSIONS
The case illustrates intraventricular polymyxin B can be a therapeutic option against extensively drug-resistant ventriculitis.
背景
近年来，医院获得性脑室炎/脑膜炎（尤其是由耐药菌株引起的脑室炎/脑膜炎）显著增加。然而，由于大多数抗生素通过血脑屏障的穿透率较低，因此对于脑室炎/脑膜炎的治疗选择有限。
病例介绍
一名 57 岁男性患者因严重创伤性脑损伤行减压性颅骨切除术，后出现广泛耐药菌株引起的脑室炎。该患者成功接受了脑室和静脉注射多黏菌素 B 联合静脉注射替加环素治疗。
结论
该病例表明，脑室注射多黏菌素 B 可能是治疗广泛耐药鲍曼不动杆菌脑室炎的一种选择。
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